Results 251 to 260 of about 662,606 (363)

Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells. [PDF]

J Immunol
Nguyen AT, Fong KD, Ravesloot-Chavez MM, Pham V, Calderon J, McSorley SJ.   +5 more
europepmc   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Preliminary evaluation of a DDA cationic liposome-based pulmonary mucosal immunization platform carrying a SARS-CoV-2 spike-derived branched peptide. [PDF]

Front Immunol
Xia Z, Yang Z, Shi Z, Huang S, Xu F.
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Parenteral neonatal priming followed by heterologous mucosal booster favors IgM⁺ memory B cell induction over systemic plasma cell differentiation. [PDF]

Front Immunol
Foroutan Pajoohian P, Aradottir Pind AA, Molina Estupiñan JL, Christensen D, Pedersen GK, Olafsdottir TA, Jonsdottir I, Bjarnarson SP.   +7 more
europepmc   +1 more source

From Amyotrophic Lateral Sclerosis to Neurodegenerative Diseases: A Scoping Review of Artificial Intelligence‐Powered Chatbots for Addressing Patients' and Caregivers' Information Needs

Medicine Advances, EarlyView.
This scoping review synthesizes evidence from 24 studies (2019–2024) to examine how AI‐powered chatbots address patients' and caregivers' health information needs across diseases. Findings highlight key benefits such as accessibility, empowerment, efficiency, and personalization, alongside important limitations related to empathy, language and ...
Julie Desgroseilliers, Christine Hamel, Kathy Ogundokun, Karine Latulippe   +3 more
wiley   +1 more source

Recombinant RBD-based subunit vaccines incorporating high-frequency mutation sites elicit cross-immunity and robust protection against SARS-CoV-2. [PDF]

Front Microbiol
Ren Z, Liu X, Sun W, Gao X, Jiang W, Li Y, Hu C, Zhu M, Zhao Y, Li Y, Xia X, Yang Z, Liu J, Lv X, Wang T, Cui D.   +15 more
europepmc   +1 more source

Interdiction Models and Heuristics for Graph Propagation

Networks, EarlyView.
ABSTRACT Given a graph G=(V,E)$$ G=\left(V,E\right) $$ and a set S⊂V$$ S\subset V $$ of activated/infected nodes, we consider the problem of determining the set of c$$ c $$ nodes that minimizes the network propagation on the subgraph that results from the removal of those c$$ c $$ nodes. To measure network propagation, we assume that a node i$$ i $$ is
Agostinho Agra, José Maria Samuco
wiley   +1 more source

An mRNA-LNP vaccine expressing TP0435 provides protective immunity in rabbits against <i>Treponema pallidum</i> challenge. [PDF]

Emerg Microbes Infect
Lu Z, Lu Y, Liu D, Du F, Wu Q, Liao G, Wu Y, Zhang RL, Zhou J, Wang QQ.   +9 more
europepmc   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source