Results 71 to 80 of about 645,855 (340)
Advanced Science, EarlyView.This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen +8 more
wiley +1 more source
Infectious Diseases of Poverty, 2017 Background Communication for Development (C4D) is a strategy promoted by the United Nations Children’s Fund to foster positive and measurable changes at the individual, family, community, social, and policy levels of society.
Ming Lu +12 more
doaj +1 more source
Advanced Science, EarlyView.A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu +8 more
wiley +1 more source
Zhongguo gonggong weishengObjectiveTo analyze the prevalence of pertussis in Hangzhou city from 2010 to 2022 and predict its incidence rate using an autoregressive integrated moving average (ARIMA) model, with the goal of improving prevention and control measures.
Yingying YANG +13 more
doaj +1 more source
Impact of Prenatal Checkups of Mothers and Immunization of Children on the Health Status of Children (0-3 years) - A Study in Rural areas of Aligarh District, Uttar Pradesh. [PDF]
, 2010 Background and objectives: A survey based study on rural areas of Aligarh District was conducted to assess the prenatal checkups pregnant women and its effects on health status of children between the age of (0-3 years), and immunization received by ...
Alim, Farzana, Jahan, Farhat
core +1 more source
Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. [PDF]
, 2012 Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before ...
Aliesky, Holly A +4 more
core +2 more sources
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Human Vaccines & ImmunotherapeuticsThe high coverage of mumps-containing vaccine (MuCV) has effectively controlled the mumps incidence, while the prevention and control of breakthrough cases has become a prominent problem.
Yang Liu +7 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2023 Parents are facing tremendous stress in relation to the COVID-19 pandemic and the effectiveness of the COVID-19 vaccination program for children. We aimed to investigate parents’ willingness to vaccinate their children against COVID-19 in North Kivu ...
Stephane Hans Bateyi Mustafa +2 more
doaj +1 more source
Spreading with immunization in high dimensions [PDF]
, 2004 We investigate a model of epidemic spreading with partial immunization which is controlled by two probabilities, namely, for first infections, $p_0$, and reinfections, $p$.
Bunde A +33 more
core +1 more source