Results 191 to 200 of about 297,127 (263)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA. [PDF]

PLoS Pathog
Xu J, Li H, Li J, Dong B, Li H, Sun H, Zhang J, Gao J, Gong Y, Liu X, Nian Z, Wang T, Li N, Jiang J, Peng Z.   +14 more
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Serum albumin maintains Wnt3a water solubility and activity. [PDF]

Commun Biol
Yeo JH, Chae J, Kwon SS, Han J, Kusen I, Lim JY, Lee H, Kim H, Haam S, Cheong JH, Kim T, Moon SJ, Jung YO, Lee J, Kim CH.   +14 more
europepmc   +1 more source

Systemic Everolimus Does Not Block the Incubation of Methamphetamine-Craving: A Dose-Response Study. [PDF]

Addict Biol
Cano FJ, Smith KE, Stuemke K, Jotwani A, Lassers E, Nelson HM, Adler SD, Huerta Sanchez LL, Denning CJE, Davantes SM, Ibarra CA, Kippin TE, Szumlinski KK.   +12 more
europepmc   +1 more source

<i>Coxiella burnetii</i> inhibits host cell death by ubiquitination-induced inactivation of an apoptosis nuclease. [PDF]

mLife
Zhang Y, Jiao J, Liu S, Yuan J, Liu S, Chen TT, Ouyang S, Fu J, Luo ZQ.   +8 more
europepmc   +1 more source

Zinc Oxide Nanoparticles Promote Apoptosis of Granulosa Cell Through Autophagy-Associated Suppression of Notch3 Signaling. [PDF]

Antioxidants (Basel)
Wang Z, Wang Y, Liu G, Lv J, Tang H, Jiang Z.   +5 more
europepmc   +1 more source

Oncogenic EGFR rewires STING-TBK1 signalosomes to license DNA damage tolerance in NSCLC. [PDF]

EMBO J
Shen Q, Mei C, Chen Y, Zhang Q, Wu Q, Yu X, Zhang F, Liu S, Chen C, Ye C, Zhang Q, Feng XH, Shen L, Song H, Liang T, Song P, Xia B, Xu P.   +17 more
europepmc   +1 more source

Glycolipid MPIase is essential for the TAT (twin-arginine translocation) pathway. [PDF]

Elife
Nishikawa H, Yamamoto N, Kunezaki H, Shirogane Y, Kanno K, Sawasato K, Yamada M, Nishiyama KI.   +7 more
europepmc   +1 more source