Results 161 to 170 of about 335,110 (302)

GSK3β and Plk1 sequentially phosphorylate ATP-citrate lyase to promote homologous recombination. [PDF]

Sci Adv
Zhou S, Zhou X, Chen Q, Yuan X, Zhu S, Huang J, Wang F, Yan H.   +7 more
europepmc   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Aurora kinase a phosphorylates and stabilizes UHRF1 to maintain DNA methylation and prostate cancer cell survival. [PDF]

Epigenetics
Xiang Q, Peng Y, Ye Y, Li X.
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Herpesviruses hijack ISGylation to promote viral capsid assembly. [PDF]

Sci Adv
Li S, Feng S, Liu Y, Qin C, Zhang J, Saito T, Xie X, Fu W, Wang R, Zheng Y, Shu Z, Yeh W, Sasaki S, Tjokro N, Chen L, Munger J, Yuan W, Jung J, Chen C, Feng P.   +19 more
europepmc   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Enteric Coronaviruses in Primates [PDF]

, 1988
C.‐P. Czerny, Eichhorn, Werner, W. Eichhorn, Czerny, C. P.   +3 more
core   +2 more sources

Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK. [PDF]

Signal Transduct Target Ther
Yang Y, Chen H, Xiang S, Wei Y, Zhang L, Sun A, E X, Wu F, Luo N, Liang F, Wu X, Wang C, Chen Z, Zhang Q, Chen X, Wu Q, Han Z, Li C, Yin R, Ren G, Li J, Zhao K, Gao H, Wang R, Yu M, Yang X.   +25 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

EspF acts as a molecular scaffold to facilitate TRIM25-mediated NLRP3 inflammasome activation during mycobacterial infection. [PDF]

Virulence
Yang Y, Han Y, Wu L, Zang X, Xu W, Li Y, Xu A, Jiang H, Fan J, Cui L, Huang B, He G, Song H.   +12 more
europepmc   +1 more source