Results 171 to 180 of about 4,533 (248)

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Safety of and serological response to a new canine distemper‐parvovirus combination vaccine in domestic ferrets

Veterinary Record, EarlyView.
Abstract Background Pet ferrets are typically vaccinated against distemper using a canine multivalent vaccine despite the lack of relevant safety or efficacy data. Here, we investigate the safety of a novel live canine parvovirus type 2c (CPV‐2c) vaccine strain and the efficacy of the live Onderstepoort canine distemper virus (CDV) vaccine strain used ...
Jacqueline Pearce, Léon Peeters, Ellen Versmissen, David Sutton, Ian Tarpey   +4 more
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Herpesvirus and Adenotonsillar Hypertrophy in Chinese Children: An Epidemiological and Clinical Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To investigate the possible association between adenotonsillar hypertrophy (ATH) and herpesviral infections in children, and to examine correlations between specific viral detection and clinical characteristics. Methods We enrolled 43 children aged 3–14 years with ATH (mean age 76.56 ± 25.65 months; 31 boys).
Ting‐Ting Ji, Miao Fan, Dan Yu, Xin Ni, Xiao‐Dan Li, Xin‐Yu Wang, Lu Lu, Wen Su, Li‐Xing Tang, Wei Zhang, Xiao Xiao, Yang Han, Lin Mei, Sheng‐Cai Wang   +13 more
wiley   +1 more source

Investigation of the Efficacy and Safety of TO‐208 in Patients 2 Years of Age or Older With Molluscum Contagiosum in Japan: A Randomized, Double‐Blind, Placebo‐Controlled, Phase 3 Study (208‐3‐1) and Its Open‐Label Extension

The Journal of Dermatology, EarlyView.
ABSTRACT Molluscum contagiosum (MC) is a common viral skin infection in children. In the two Phase 3 Cantharidin Application in Molluscum Patients [CAMP‐1 and CAMP‐2] studies, cantharidin, a drug‐device combination containing cantharidin (0.7%), a topical vesicant, was significantly superior to placebo in achieving complete clearance of MC lesions at ...
Takafumi Kadono, Tsuyoshi Mitsuishi, Akira Shimizu, Yasushi Suga, Daisuke Watanabe, Shinya Kaneko, Ryota Ishiwata, Thomas F. Haws, Susan Cutler, Atsuyuki Igarashi   +9 more
wiley   +1 more source

Males are worse mothers: Comparing care patterns in a facultatively caring beetle

Insect Science, EarlyView.
Why should biparental care exist if offspring fare just as well when only one parent is present? In the facultatively dependent burying beetle, Nicrophorus vespilloides, manipulating environmental quality reveals that biparental care benefits offspring in form of lower personal immune requirement and parents in term of weight gain.
Leon Müller, Patrick Limburg, Maximilian Körner   +2 more
wiley   +1 more source

Living Low and Dry: Costs of and Resilience to Soil Hydric Stress in a Fossorial Amphisbaenian Reptile

Integrative Zoology, EarlyView.
Soil drought imposes moderate, temporary costs on a strictly fossorial amphisbaenian reptile. However, these animals seem to cope with, at least, moderately short droughts thanks to their peculiar adaptations to living in an underground environment. ABSTRACT The physiological traits of animals can be strongly influenced by climatic fluctuations, and ...
José Martín, Álvaro Navarro‐Castilla, Alejandro de la Concha, José Javier Cuervo, Isabel Barja, Pilar López   +5 more
wiley   +1 more source

Saving Water to Survive: Alternative Water Loss Strategies Could Explain Color Polymorphism Maintenance in a Lacertid Lizard

Integrative Zoology, EarlyView.
We demonstrate that red male Podarcis muralis exhibit higher evaporative water loss compared to other morphs, indicating a physiological strategy that prioritizes hydroregulation over fine thermoregulation. This suggests red morphs are adapted to cooler, wetter niches, while white and yellow morphs possess superior water conservation mechanisms to ...
Roberto Sacchi, Stefano Scali, Thomas Dadda, Federico Storniolo, Marco A. L. Zuffi, Andrea Melotto, Stéphanie Sherpa, Federica Frongia, Danny Tassi, Gentile Francesco Ficetola, Marco Mangiacotti   +10 more
wiley   +1 more source

Parasites at the Summit: Unexpected Geographic Distribution of the Blood Parasite Lineage Found in the Endangered Giant Lizard of Tenerife

Integrative Zoology, EarlyView.
We combined microscopic screening and molecular phylogenetic analyses to characterize blood parasites infecting Gallotia intermedia from the coastal cliffs of Montaña de Guaza and to place these infections in a broader biogeographic context. We detected apicomplexan parasites of the genus Karyolysus infecting 53.6% of G.
Rodrigo Megía‐Palma, Gonzalo Albaladejo‐Robles, Gemma Palomar, Javier Martínez, Anamarija Žagar, Alejandro Escánez‐Pérez, Miguel A. Carretero, Wiesław Babik, Santiago Merino   +8 more
wiley   +1 more source