Results 81 to 90 of about 89,131 (302)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

237. Elizabethkingia species: An Emerging Cause of Healthcare-Associated Bloodstream Infection Among Immunocompromised Hosts [PDF]

, 2023
Adam G. Stewart, Kevin B. Laupland, Felicity Edwards, David L. Paterson, Patrick N. A. Harris   +4 more
openalex   +1 more source

Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability

Animal Models and Experimental Medicine, EarlyView.
Optimized dengue fever animal model: IFNAR−/− BALB/c mice with intraperitoneal injection. Background screening: Between IFNAR−/− (BALB/c, C57BL/6) and AG129 mice, IFNAR−/−BALB/c exhibited the most severe symptoms: (1) highest weight loss and clinical scores; (2) peak viremia (5.44 log10 RNA copies/mL, day 4); (3) significant organ damage (liver/brain ...
Dan Liao, Ming Zhong, Wenjiang Zheng, Zhendong Guo, Ye Zhou, Qiuhong Li, Lijuan Qiu, Liangwen Yu, Haishan Long, Geng Li   +9 more
wiley   +1 more source

Elderly diabetic patient with surgical site mucormycosis extending to bowel

Journal of Global Infectious Diseases, 2010
Mucormycosis is rare in clinical practice. Most infections are acquired by inhalation; other portals of entry are traumatic implantation and ingestion in immunocompromised host.
Atul K Patel, Himanshu J Vora, Ketan K Patel, Bhavin Patel   +3 more
doaj   +1 more source

A Fatal Case of Neuroinvasive West Nile Virus Infection in an Immunocompromised Host [PDF]

, 2017
Justin Allen, Jennifer Conard, Michael Wang   +2 more
openalex   +1 more source

Coinfection of Toxoplasma Gondii and Intestinal Parasites among Elderly Immunocompromised Patients

Elderly Health Journal, 2020
Introduction: Patients with cancer and hemodialysis are prone to opportunistic infections. The present research aims to examine the frequency of Toxoplasmosis and intestinal parasites in these patients.
Mohammad Reza Mahmoudi, Behnaz Rahmati
doaj  

Herpetic zoster folliculitis in the immunocompromised host [PDF]

, 2015
Sheila Shaigany, Ellen Dabela, Sameera Husain, Marc E. Grossman   +3 more
openalex   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cryptosporidiosis in a Zoonotic Gastrointestinal Disorder Perspective

Journal of Tropical Medicine
Cryptosporidium infection is highly prevalent among immunocompromised patients with Acquired Immunodeficiency Syndrome, cancer, primary immunodeficiency, and organ transplant recipients.
Thivya Balendran, Devika Iddawela, Sajanee Lenadora   +2 more
doaj   +1 more source