Results 61 to 70 of about 98,021 (296)

Bilateral endogenous Trichoderma endophthalmitis in an immunocompromised host

American Journal of Ophthalmology Case Reports, 2021
Purpose: To report a case of bilateral endogenous endophthalmitis, caused by the Trichoderma species, in a severely immunocompromised patient. Observations: A 39-year-old man with acute myeloid leukemia, in a relapsed state on high-dose chemotherapy ...
Abdulaziz Al-Shehri, Saud Aljohani, Valmore A. Semidey   +2 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Host Immunity and Francisella tularensis: A Review of Tularemia in Immunocompromised Patients

, 2021
Tularemia, caused by the bacterium Francisella tularensis, is an infrequent zoonotic infection, well known in immunocompetent (but poorly described in immunocompromised) patients.
Cécile Le Brun, Adrien Lemaignen, Olivier Bahuaud   +2 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Candida albicans keratitis in an immunocompromised patient

, 2010
H Mohammed J Hassan1, Theocharis Papanikolaou2, Georgios Mariatos1, Amany Hammad3, Hala Hassan41Ophthalmology Department, Barnsley Hospital NHS Foundation Trust, South Yorkshire, England, UK; 2Ophthalmology Department, Cambridge University Hospitals NHS ...
H Mohammed J Hassan, Mohammed Hassan, Georgios Mariatos, Theocharis Papanikolaou, et al   +4 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Is phage therapy acceptable in the immunocompromised host?

, 2008
SummaryOver the last decade, bacteriophages (bacterial viruses) have emerged as the major alternative to antibiotics in the treatment of antibiotic-resistant infections. While a considerable body of evidence has accumulated for the efficacy and safety of
Jan Borysowski, Borysowski, Jan, Górski, Andrzej, Andrzej Górski   +3 more
core   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host

, 2016
Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host species, while others are host-adapted, infecting ...
Heath, JN, Forbester, Jessica L., Hadfield, J, Parkhill, J, Wileman, T, Harris, Simon R., Harris, Simon R, Maclennan, Calman, Gkrania-Klotsas, Effrossyni, MacLennan, Calman A, Carmichael, Andrew, MacLennan, Calman A., Doffinger, R, Cooke, FJ, Heath, Jennifer N, Kingsley, Robert A, Harris, SR, Gkrania-Klotsas, E, Lever, Andrew ML, Kay, S, Doffinger, Rainer, Cooke, Fiona J., Goulding, David, Klemm, Elizabeth J., Klemm, EJ, Forbester, JL, Lane, L, Otto, Thomas D, Otto, TD, Carmichael, A, Otto, Thomas D., Clare, Simon, Hale, C, Maclennan, CA, Clare, S, Hadfield, James, Heath, Jennifer N., Wileman, Thomas, Lane, Leanne, Hale, Christine, Lever, Andrew M. L., Kingsley, Robert A., Kingsley, RA, Dougan, Gordon, Parkhill, Julian, Forbester, Jessica L, Lever, AML, Klemm, Elizabeth J, Cooke, Fiona J, Kumararatne, Dinakantha, Kane, Leanne, Goulding, D, Kay, Sally, Kumararatne, D, Dougan, G   +54 more
core   +1 more source