Results 81 to 90 of about 98,021 (296)

Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment [PDF]

Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use.
Dalm, Virgil A.S.H., de Graaf, Miranda, Villabruna, Nele, Koopmans, Marion P.G., Sol Ribó Pons, Schapendonk, Claudia M.E., Jeroen J.A. van Kampen, Jenny I.J. Meier, Ian Goodfellow, Nieuwenhuijse, David, Ribó Pons, Sol, Fraaij, Pieter L.A., Miranda de Graaf, Izquierdo-Lara, Ray W., Hesselink, Dennis A.; id_orcid, Goodfellow, Ian, David Nieuwenhuijse, Virgil A.S.H. Dalm, Ray W. Izquierdo-Lara, Nele Villabruna, Claudia M.E. Schapendonk, Pieter L.A. Fraaij, van Kampen, Jeroen J.A., Dennis A. Hesselink, Meier, Jenny I.J., Marion P.G. Koopmans   +25 more
core   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Animal Models and Experimental Medicine, EarlyView.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li, Ziqing Jia, Zhe Cong, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Fei Wang, Jiasen Yang, Ting Chen, Jingjing Zhang, Dong Zhang, Jing Xue   +11 more
wiley   +1 more source

Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin

Brazilian Journal of Infectious Diseases
Disseminated strongyloidiasis is a disease with high mortality rate, especially in immunocompromised individuals. Paralytic ileus and intestinal malabsorption are frequent symptoms caused by this severe disease.
Edmilson Bastos de Moura, Marcelo de Oliveira Maia, Monalisa Ghazi, Fábio Ferreira Amorim, Henrique Marconi Pinhati   +4 more
doaj   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research, EarlyView.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
wiley   +1 more source

Diagnostica microbiologica delle infezioni associate all’utilizzo di cateteri venosi centrali (CVC): considerazioni generali e studio in pazienti immunocompromessi

Microbiologia Medica, 2006
Central venous catheterization today is essential for the intensive management of both medical and surgical patients (for the administration of iv fluids, medications, blood products and parenteral nutrition fluids, to monitor hemodynamic status and to ...
Giancarlo Basaglia, Sandro Stocco Calzavara, Antonella Pancino, Paola Sperandio, Maria Luisa Tomasini, Paolo De Paoli   +5 more
doaj   +1 more source

Bacterial and Mycotic Infections in immunocompromised hosts: Clinical and Microbiological Aspects

, 2013
Causative organisms (Fungi) 2. Pathological Basis and Morphological Features 3. Gynecological Infections in Immunocompromised Hosts 4. Sexually Transmitted Diseases 5.
Shagufta T. Mufti, MASCELLINO, Maria Teresa, Madhu Dyavaiah, Tim Sandle   +3 more
core  

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Human parvovirus B19 infection in an immunocompromised host

Clinical Case Reports, 2020
Serologic testing may be negative in immunocompromised hosts due to inadequate IgG and IgM response. The classic bone marrow findings of viral inclusions and giant proerythroblasts are pathognomonic for active infection and should prompt initiation of ...
Soumya Pandey
doaj   +1 more source

Modeling Human Graft-Versus-Host Disease in Immunocompromised Mice

, 2016
Hematopoietic stem cell transplantation (HSCT) from an allogeneic donor is an effective form of cancer immunotherapy, especially for acute leukemias.
Attilio Bondanza, BONDANZA, ATTILIO, Barbara Camisa, Norelli, Margherita, Camisa, Barbara, Margherita Norelli   +5 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source