Results 41 to 50 of about 1,275,927 (291)

Bacteremia Secondary to Uncommon Gram-Negative Bacilli Transmitted From the Canine in a Patient With Multiple Myeloma

Journal of Investigative Medicine High Impact Case Reports, 2020
Sphingobacterium multivorum is a gram-negative rod found in the environment and rarely associated with human infections. Sphingobacterium is the causative agent of infections in an immunocompromised host in most cases. We report a rare case of cellulitis
Venu Madhav Konala MD, Srikanth Naramala MD, Subhashish Bose MD, Vijay Gayam MD, Bhaskar Reddy Madhira MD, Sreedhar Adapa MD   +5 more
doaj   +1 more source

Antigenic evolution of SARS-CoV-2 in immunocompromised hosts [PDF]

, 2023
Prolonged infections of immunocompromised individuals have been proposed as a crucial source of new variants of SARS-CoV-2 during the COVID-19 pandemic. In principle, sustained within-host antigenic evolution in immunocompromised hosts could allow novel ...
Smith, Cameron, Ashby, Ben
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts.

, 2022
BackgroundHost gene expression has emerged as a complementary strategy to pathogen detection tests for the discrimination of bacterial and viral infection. The impact of immunocompromise on host-response tests remains unknown.
Ginsburg, Geoffrey S, Mahle, Rachael E, Woods, Christopher W, Steinbrink, Julie M, Suchindran, Sunil, Henao, Ricardo, Burke, Thomas W, McClain, Micah T, Tsalik, Ephraim L   +8 more
core   +1 more source

SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient [PDF]

, 2022
Objectives: Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants.
Matteo Pagliari, Giussani, Edoardo, Maria Varotto, Francesca Merola, Valeria D'Amico, Maria Teresa Giordani, Quaranta, Erika Giorgia, Fusaro, Alice, Erika Giorgia Quaranta, D'Amico, Valeria, Giordani, Maria Teresa, Antico, Antonio, Isabella Monne, Alice Fusaro, Zoppelletto, Maira, Calogero Terregino, Pagliari, Matteo, Stefanelli, Paola, Varotto, Maria, Terregino, Calogero, Monne, Isabella, Maira Zoppelletto, Paola Stefanelli, Antonio Antico, Edoardo Giussani, Merola, Francesca   +25 more
core   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Management of Norovirus Infection in Solid Organ Transplant Recipients: A Scoping Review

Transplantation Direct
Background. Norovirus infection causes significant morbidity in solid organ transplant (SOT) recipients, yet few treatments are available, and evidence for efficacy is sparse.
Thida Maung Myint, MBBS, Jonathan Hand, MD, Adam Lowe, MD, Camille N. Kotton, MD, Sharon C-A Chen, PhD, Justin Beardsley, PhD, Armando Teixeira-Pinto, PhD, Germaine Wong, PhD, Samuel Chan, PhD   +8 more
doaj   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins

International Journal of Infectious Diseases, 2019
Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive ...
Davide Mangioni, Giacomo Grasselli, Chiara Abbruzzese, Antonio Muscatello, Andrea Gori, Alessandra Bandera   +5 more
doaj   +1 more source