Results 271 to 280 of about 174,366 (328)

Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype. [PDF]

Aging Cell
Thoms HC, Brant TS, Duckett K, Yang Y, Dong J, Wang H, Derby F, Akeke OF, Al-Alayeen F, Newell A, Manasterski P, Gopalakrishnan A, Mann D, Millar FR, Von Kriegsheim A, Acosta JC, Oakley F, Stark LA.   +17 more
europepmc   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Comprehensive profiling of Aβ40 and Aβ42 fibril‐interacting proteins reveals PRKCG as a drug‐targetable regulator of amyloidogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Proteins interacting with amyloid beta (Aβ) fibrils could be key to plaque formation in Alzheimer's disease (AD) and represent potential biomarkers and therapeutic targets. Previous proteomic studies using microdissected plaques might have captured non‐specific components rather than true Aβ interactors.
Ana Montero‐Calle, Raquel Coronel, Juliana Manosalva, Diego Megías, Vivian de los Ríos, Alberto Rábano, Alberto Peláez‐García, Javier Martínez‐Useros, María Jesús Fernández‐Aceñero, Isabel Liste, Rodrigo Barderas   +10 more
wiley   +1 more source

Practical implications of the World Health Organization Reporting System for Lymph Node, Spleen, and Thymus Cytopathology: Categories and ancillary testing for subtyping of hematolymphoid tumors on FNA biopsy cytopathology using a pattern‐based approach

Cancer Cytopathology, Volume 134, Issue 1, January 2026.
Abstract The objective of the recently published World Health Organization Reporting System for Lymph Node, Spleen, and Thymus Cytopathology (WHO system) is to standardize the diagnostic approach to fine‐needle aspiration biopsies of hematolymphoid tissues.
Mats Ehinger, Maria Calaminici, Immacolata Cozzolino, Pio Zeppa, Andrew S. Field   +4 more
wiley   +1 more source

Fine‐needle aspiration cytology reduces the frequency of surgeries for malignant salivary gland tumors

Cancer Cytopathology, Volume 134, Issue 1, January 2026.
Abstract Background Salivary gland tumors are rare and heterogeneous head and neck neoplasms. Preoperative distinction between benign and malignant lesions is challenging because imaging is often insufficient. Fine‐needle aspiration cytology (FNAC) combined with the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) provides standardized ...
Marcel Mayer, Sofia Kourou, Marwan Alfarra, Charlotte Laatz, Kevin Hansen, Julia Esser, Hans Nikolaus Caspar Eckel, Kathrin Möllenhoff, Lena Hieggelke, Marianne Engels, Christoph Arolt, Alexander Quaas, Philipp Wolber, Louis Jansen, Lisa Nachtsheim, Jens Peter Klussmann, Sami Shabli   +16 more
wiley   +1 more source

Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DFNB16 is among the most prevalent forms of congenital deafness, caused by mutations in the Stereocilin gene. Although no treatment currently exists, gene therapy represents a promising curative approach. Here, we demonstrate that AAV‐mediated gene delivery in a DFNB16 mouse model restored both peripheral hearing and central auditory processing ...
Sepideh Iranfar, Sophie Bagur, Chloé Felgerolle, Maxence Cornille, Najate Benamer, Hélène Le Ribeuz, Marie Giorgi, Sara Jamali, Amel Saoudi, Marie‐José Lecomte, Vincent Michel, Brice Bathellier, Saaid Safieddine   +12 more
wiley   +1 more source

Synergistic Combination of Additive One‐ and Two‐Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis–on–a–Chip Systems

Engineering in Life Sciences, Volume 26, Issue 1, January 2026.
ABSTRACT Tissue engineering, and in particular the development of organ‐on‐a‐chip (OOC) models, holds significant promise for advancing personalized medicine and reducing the use of animal models. The integration of microfluidics and advanced biomaterials in OOC systems provides controlled microenvironments and fosters the creation of physiologically ...
Daria Sokoliuk, Rizlene Bouhaya, Peter Haeger, Kathrin Godthardt, Daniel Fetting, Lenard Spiecker, Heinrich Spiecker, Alexander Rockenbach, Holger Rothe, Klaus Liefeith, Doris Heinrich   +10 more
wiley   +1 more source

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source