Results 281 to 290 of about 171,680 (341)

A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
Incubation of esophageal epithelial cells with a weakly acidic (pH 5) bile salt (deoxycholic acid) induces translocation of HMGB1 from the nucleus to the cytosol, and its subsequent release from the cell. This process can be ameliorated by pre‐treatment with the antioxidant, curcumin.
Tom Leech   +4 more
wiley   +1 more source

Immunization With Bovine Milk Casein Results in Enteric Nervous System Pathology in a Mouse Model of Neuroinflammation

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
Experimental study design. Mice were immunized with either α‐Lactalbumin or casein, and the resulting pathology of the enteric nervous system (ENS) was assessed using electron microscopy and immunofluorescence imaging. In vitro culture of isolated cells of the ENS was used to complement the in vivo findings.
Rittika Chunder   +5 more
wiley   +1 more source

Cytotoxicity of Atropisomeric [1,1′‐Binaphthalene]‐2,2′‐Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure–Activity Relationships, and Mechanism

open access: yesChemMedChem, Volume 20, Issue 19, October 6, 2025.
It is reported for the first time that atropisomeric (R)‐[1,1′‐binaphthalene]‐2,2′‐diamine (R‐BINAM, 1(R)), but not (S)‐[1,1′‐binaphthalene]‐2,2′‐diamine (S‐BINAM, 1(S)), is a moderately potent spindle poison, causing antiproliferation, depolymerization of microtubules, multipolar spindles, pericentriolar material (PCM) fragmentation, mitotic ...
Malte Eichelbaum, Patrick J. Bednarski
wiley   +1 more source

Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins. [PDF]

open access: yesJ Cell Biol
Hasegawa-Ogawa M   +6 more
europepmc   +1 more source

Astrocyte Interactions With Ti3C2Tx MXene Flakes: Insights Into Viability, Morphology, and Functionality

open access: yesAdvanced Materials Interfaces, Volume 12, Issue 20, October 27, 2025.
This study presents the first systematic evaluation of interactions between astrocytes and Ti3C2TX MXene flakes, a 2D nanomaterial with emerging neuroelectronic applications. Using a multimodal approach, including viability assays, morphometric analysis, and calcium imaging, this work demonstrates high biocompatibility and preserved function in ...
Dimitris Boufidis   +7 more
wiley   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

open access: yesAdvanced Therapeutics, Volume 8, Issue 10, October 2025.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam   +5 more
wiley   +1 more source

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