Results 291 to 300 of about 171,680 (341)

Detection of Fusarium solani using cutinase antibody and its application in diagnosing fungal keratitis in an animal model. [PDF]

PLoS One
Jo HJ, Kim MJ, Lee HA, Quan FS, Kong HH, Moon EK.   +5 more
europepmc   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, Volume 12, Issue 40, October 27, 2025.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia. [PDF]

Glia
Mishra S, Morshed N, Sidhu SB, Kinoshita C, Stevens B, Jayadev S, Young JE.   +6 more
europepmc   +1 more source

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source

RAB23 loss-of-function mutation causes context-dependent ciliopathy in Carpenter syndrome. [PDF]

PLoS Genet
Leong WY, Tung WL, Wilkie AOM, Hor CHH.
europepmc   +1 more source

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, Volume 12, Issue 39, October 20, 2025.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin-411 and Its Derived Peptide. [PDF]

Glia
Sasaki B, Oishi M, Aoki T, Hyodo M, Onchi C, Yamada N, Misawa H, Yamada M, Hayashi C, Sekiguchi K, Hamada K, Yamada Y, Kikkawa Y, Nomizu M, Suzuki N.   +14 more
europepmc   +1 more source

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau. [PDF]

Mol Psychiatry
Iyer AK, Vermunt L, Mirfakhar FS, Minaya M, Acquarone M, Koppisetti RK, Renganathan A, You SF, Danhash EP, Schache KJ, Verbeck A, Galasso G, Lee SM, Huang G, Miller KJ, Marsh J, Nana AL, Spina S, Seeley WW, Grinberg LT, Temple S, Teunissen CE, Sato C, Karch CM.   +23 more
europepmc   +1 more source

Commentary: Lung enteric-type adenocarcinoma with gastric metastasis: a rare case report and literature review. [PDF]

Front Immunol
Huang G, Zhao C.
europepmc   +1 more source

The Assessment of Bioactivity and Biological Responsiveness in Bioactive Glasses and Ceramics: A Review of Available Techniques. [PDF]

Materials (Basel)
De Micco S, Bellucci D, Cannillo V.
europepmc   +1 more source