Results 51 to 60 of about 166,510 (294)

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Bronchoscopy and Lung Fine-Needle Aspiration for Antemortem Evaluation of Pulmonary Involvement in Dogs with Naturally Occurring Canine Leishmaniosis

Pathogens, 2022
Clinical manifestations from the lower respiratory tract are rare in canine leishmaniosis (CanL), making bronchoscopy and lung fine-needle aspiration (FNA) seldomly justified.
Ioannis Kavarnos, Dimitra Pardali, Georgia D. Brellou, Elias Papadopoulos, Maria Kritsepi-Konstantinou, Katerina K. Adamama-Moraitou   +5 more
doaj   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Antibody Selection for Cancer Target Validation of FSH-Receptor in Immunohistochemical Settings

Antibodies, 2017
Background: The follicle-stimulating hormone (FSH)-receptor (FSHR) has been reported to be an attractive target for antibody therapy in human cancer. However, divergent immunohistochemical (IHC) findings have been reported for FSHR expression in tumor ...
Nina Moeker, Solveig Peters, Robert Rauchenberger, Nicolae Ghinea, Christian Kunz   +4 more
doaj   +1 more source

Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]

, 2018
The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao, Tang, Ronald, Yang, Xian-Jie, Zhang, Xiang-Mei   +3 more
core   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Validation and Implementation of OptiView and EnVision FLEX Detection Systems for Immunocytochemical Staining Protocols of the Ten Most Commonly Used Diagnostic Markers in Routine Cytopathological Practice

Diagnostics
The withdrawal of the iView detection system (iV) forced many cytopathology laboratories, including ours, to substitute immunocytochemical (ICC) staining protocols for routine practice with other detection systems. Our objective was to optimize, validate,
Anja Dremelj, Simona Miceska, Anamarija Kuhar, Natasa Nolde, Veronika Kloboves-Prevodnik   +4 more
doaj   +1 more source

Diagnosis of precancerous lesions of the breast

Zaporožskij Medicinskij Žurnal, 2020
The purpose of this work is to determine the optimal markers for clarifying the degree of proliferative activity in benign breast lesions, which can be used in surgical treatment planning. Materials and methods. The immunocytochemical results of tumor
D. I. Kebalo, N. P. Miroshnykova, O. P. Shershniova, S. M. Pashchenko, E. D. Zvantseva   +4 more
doaj   +1 more source

Neuropeptides of root-knot nematodes: functional significance in parasite locomotions (short review)

Российский паразитологический журнал, 2023
The purpose of the research is to analyze the literature devoted to the study of the physiological role and functional significance of biologically active substances: FMRFamide-like neuropeptides in the locomotion of root-knot nematodes Meloidogyne ...
T. A. Milyutina, Zh. V. Udalova
doaj   +1 more source

C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors [PDF]

, 2000
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional regulation at central excitatory synapses.
Kennedy, Mary B., Köhr, Georg, Schenker, Leslie T., Schulz, Torsten W., Seeburg, Peter H., Steigerwald, Frank   +5 more
core   +1 more source