Results 211 to 220 of about 238,930 (305)

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

Advanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang, Jinlei Jiang, Zhengting Wang, Shuqi Liu, Wei Wang, Xi Chen, Qirui Zhao, Xinyuan Cui, Cheng Zhou, Shengsheng Cui, Daxiang Cui   +10 more
wiley   +1 more source

Safety, Tolerability, and Immunogenicity of the TANCoV-1.3.20 SARS-CoV-2 Vaccine Among Healthy Participants in Tanzania: Protocol for a Multisite, Phase 1/2a, Double-Blinded Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Judicate GP, Missanga M, Senkoro M, Kapesa E, Chiwerengo N, Ferdinand R, Kagaruki G, Kimaro G, Ngadaya E, Kivuyo SL, Buma D, Sudi L, Kisinda A, Maganga L, Pamba D, Mwakisisile J, Olomi W, Ntinginya Elias N, Aboud S, Wambura P, Mfinanga S.   +20 more
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Application and Research Progress of Self-Assembling Protein Nanoparticles in Vaccine Development. [PDF]

Int J Mol Sci
Zhang Y, Ru Y, Li X, Wang G, Hu Y, Jian Y, Ma L.   +6 more
europepmc   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB. [PDF]

Front Immunol
Voigt E, Alsharaydeh A, Kasal DN, Jennewein MF, Brandt DS, Lin S, Singh J, Bakken J, Mohamath R, Fusco P, Torrelles JB, Beamer G, Fox CB.   +12 more
europepmc   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Immunogenicity of an Inactivated DIVA Lumpy Skin Disease Virus Vaccine in Guinea Pigs and Lactating Cows, and Its Effects on Cow Lactation. [PDF]

Vaccines (Basel)
Testa L, Capista S, Serroni A, Iorio M, Ronchi GF, Traini S, Matteo ID, Laguardia C, Profeta F, Palucci C, Caporale M, Saletti MA, Marchegiano A, Pinoni C, Rossi E, Salini R, Aretusi G, Armillotta G, Fanì S, Parolini F, Ventura MD, Mercante MT.   +21 more
europepmc   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Allele-specific KRAS signaling: shaping tumor immunity and therapeutic response in lung adenocarcinoma. [PDF]

Signal Transduct Target Ther
Papavassiliou KA, Stravopodis DJ, Papavassiliou AG.   +2 more
europepmc   +1 more source