Results 111 to 120 of about 848,800 (312)

Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend, Julie MJ Laffy, Yu-Chang Bryan Wu, Joselli Silva O'Hare, Victoria Martin, David Kipling, Franca Fraternali, Deborah K Dunn-Walters   +7 more
doaj   +1 more source

Tumor-Associated Disialylated Glycosphingolipid Antigen-Revealing Antibodies Found in Melanoma Patients' Immunoglobulin Repertoire Suggest a Two-Direction Regulation Mechanism Between Immune B Cells and the Tumor

Frontiers in Immunology, 2019
There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors.
Beatrix Kotlan, Szabolcs Horvath, Klara Eles, Vanda K. Plotar, Gyorgy Naszados, Katalin Czirbesz, Miri Blank, Emil Farkas, Laszlo Toth, Jozsef Tovari, Andras Szekacs, Yehuda Shoenfeld, Maria Godeny, Miklos Kasler, Miklos Kasler, Gabriella Liszkay   +15 more
doaj   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]

, 2009
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

THE ROLE OF IgM-ENRICHED INTRAVENOUS IMMUNOGLOBULIN IN TRANSPLANTATION [PDF]

Sanamed, 2014
After organ transplantation, gamma globulin and intravenous immunoglobulin enriched with IgM are most frequently used in septic shock as early immune-support.
Szabó Judit, Smudla Anikó, Fazakas János   +2 more
doaj  

Intrathecal B-cell activation in LGI1 antibody encephalitis. [PDF]

, 2020
ObjectiveTo study intrathecal B-cell activity in leucine-rich, glioma-inactivated 1 (LGI1) antibody encephalitis. In patients with LGI1 antibodies, the lack of CSF lymphocytosis or oligoclonal bands and serum-predominant LGI1 antibodies suggests a ...
Dandekar, Ravi, Gelfand, Jeffrey M, Geschwind, Michael D, Greenfield, Ariele L, Irani, Sarosh R, Jahn, Sarah, Lehmann-Horn, Klaus, Lepennetier, Gildas, Michael, Sophia, Palanichamy, Arumugam, von Büdingen, H-Christian, Wang, Shengzhi, Wilson, Michael R, Zamvil, Scott S   +13 more
core  

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

THE CHANGES IN THE LEVEL OF BETA ENDORPHIN, INTERSLEUKIN-2, INTERLEUKIN-4, INTERLEUKIN-6, IMUNOGLOBULIN AND CORTISOL HORMONE ON THE PRACTICES OF SATRIA NUSANTARA [PDF]

, 2010
The purpose of this research is to reveal the changes of immunity at breathing exercises. This is an experimental research study. This research used “randomized pretest-posttest control group design.
Sudarko, Rumpis Agus
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