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Veterinary Immunology and Immunopathology, 2009
Canine IgE discovery and characterization historically closely paralleled that of human IgE. The reason for this would seem to be the early recognition of the spontaneous manifestation of allergic diseases in dogs that are nearly identical to human allergic diseases.
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Canine IgE discovery and characterization historically closely paralleled that of human IgE. The reason for this would seem to be the early recognition of the spontaneous manifestation of allergic diseases in dogs that are nearly identical to human allergic diseases.
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Veterinary Immunology and Immunopathology, 2009
The recognition of homocytotropic antibodies and their occurrence in response to parasite infection preceded the recognition of IgE as a distinct antibody isotype in the bovine species. Passive cutaneous anaphylaxis was an early reliable and antigen specific method to detect IgE in bovine serum.
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The recognition of homocytotropic antibodies and their occurrence in response to parasite infection preceded the recognition of IgE as a distinct antibody isotype in the bovine species. Passive cutaneous anaphylaxis was an early reliable and antigen specific method to detect IgE in bovine serum.
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The discovery of immunoglobulin E
Immunology Letters, 2016The discovery of immunoglobulin E (IgE) was a breakthrough in the field of allergy and immunology. Our understanding of mechanisms of allergic reactions and the role of IgE in these disorders has paralleled to the discovery of treatment modalities for patients with allergy. The first clue to the existence of a substance responsible for hypersensitivity
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Role of immunoglobulin E and immunoglobulin E receptors in bronchial asthma
Journal of Allergy and Clinical Immunology, 1981The molecular and cellular events involved in the immediate hypersensitivity response, illustrated in Fig. 1, have received increasing attention in recent yeass. l* 2 Not only is this response the basis for allergic diseases but also it provides a relatively simple model for immunologic activation of specific cells, which may be applicable to other ...
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Immunoglobulin E in Renal Disease
Nephron, 2008Samples of renal tissue from 373 patients were examined for the presence of immunoglobulin E (IgE) by immunofluorescent techniques. Only trace to + + amounts (on a scale of + + + +) were found in 20 patients: 4/9 with post-streptococcal acute glomerulonephritis (GN), 5/30 with GN associated with systemic lupus erythematosus, 3/20 with membranous GN, 1 ...
M R, Robertson +3 more
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Immunoglobulin E in aqueous humour
Experimental Eye Research, 1985The level of immunoglobulin E (IgE) was determined in the aqueous humour (AH) and serum by particle counting immunoassay (limit of sensitivity: 0.2 IU ml-1). This level in the AH was below 0.75 IU ml-1 in case of senile cataract (n = 22) and ranged from this assumed normal value to 550 IU ml-1 in case of uveitis (n = 37), Fuchs' cyclitis (n = 11 ...
J P, Dernouchamps +3 more
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Phosphorylation of the receptor for immunoglobulin E
Biochemistry, 1982Specific immune precipitation of immunoglobulin E(IgE)-receptor complexes from detergent extracts of 32P-labeled rat basophilic leukemia cells yielded a phosphoprotein of Mr approximately 35,000 on gel electrophoresis in sodium dodecyl sulfate.
C, Fewtrell, C L, Davis, H, Metzger
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A model of the Fc of immunoglobulin E
Molecular Immunology, 1986A model of the Fc of human IgE was constructed using the known three-dimensional structure of IgG Fc. On the basis of amino acid sequence homology, the CE2, CE3 and CE4 domains were modelled after CG3, CG2 and CG3, respectively. The mode of association of the CG2 and of the CG3 pairs of domains was assumed for the CE3 and the CE4 pairs, respectively ...
E A, Padlan, D R, Davies
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Dermographia mediated by immunoglobulin E
The American Journal of Medicine, 1973Abstract We have investigated the component in the serum of two patients with dermographia that sensitized normal skin for a wheal-flare response to scratching. Passively sensitized skin sites were more reactive six to eight hours than 1 hour after injection and sometimes remained sensitized for 10 days.
R W, Newcomb, H, Nelson
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Immunoglobulin E and bullous pemphigoid
European Journal of Dermatology, 2018Clinical features and histological findings in bullous pemphigoid (BP) suggest a Th2-oriented inflammatory reaction, especially in the early stages of the disease. Elevated total serum IgE levels, blood eosinophilia, and elevated serum levels of different soluble inflammatory Th2 response mediators have been described in large cohorts of patients with ...
Cozzani, Emanuele +3 more
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