Results 171 to 180 of about 22,044 (247)

Serum Disease-Specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry. [PDF]

Mol Cell Proteomics
Mao Y, Zhang J, Zhang Y, Hu B, Hao Y, Yuan Z, Zhao X, Wang Y, Wei Z, Yu W, Li Z.   +10 more
europepmc   +1 more source

Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Adeno‐associated virus (AAV) is a non‐enveloped DNA virus infecting a wide variety of species, tissues, and cell types, which is recognized as a safe and effective method for delivering therapeutic transgenes. AAV vector is the most popular viral gene delivery system in clinical delivery systems with unique and multiple advantages, such as ...
Ling Yin, Hongliang He, Hongliang Zhang, Yuhua Shang, Chengbo Fu, Songquan Wu, Tengchuan Jin   +6 more
wiley   +1 more source

With great power, comes great responsibility: the importance of broadly measuring Fc-mediated effector function early in the antibody development process. [PDF]

MAbs
Crescioli S, Jatiani S, Moise L.
europepmc   +1 more source

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Asymmetric N-Glycosylation in the Tailpiece of Recombinant IgA1. [PDF]

J Am Chem Soc
Peris-Díaz MD, Deslignière E, Jager S, Mokiem N, Barendregt A, Bondt A, Heck AJR.   +6 more
europepmc   +1 more source

Design and evolution of a synthetic small protein scaffold based on the WW domain

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Protein engineering is a powerful tool in biotechnology and the basis to create unprecedented sequences, structures, and functions. The WW domains are a family of naturally occurring proteins involved in the molecular recognition of proline‐rich and phosphorylated peptide sequences with relevance in cellular processes involved in human ...
Ana Margarida Gonçalves Carvalho Dias, Gonçalo Duarte Gomes Teixeira, Arménio Jorge Moura Barbosa, Joao Goncalves, Olga Iranzo, Ana Cecília Afonso Roque   +5 more
wiley   +1 more source

Anti-Tumor Activities of Anti-Siglec-15 Chimeric Heavy-Chain Antibodies. [PDF]

Int J Mol Sci
Cheng K, Guo J, Li Y, Kang Q, Wang R, Luo L, Wang W, Lu J.   +7 more
europepmc   +1 more source

Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediated glycan modulation

VIEW, Volume 6, Issue 3, June 2025.
Infertility is a global concern, with male factors contributing to nearly half of cases. This study compared glycopatterns of sperm and sperm‐derived exosomes from conventional IVF and rescue ICSI (RICSI) patients, revealing key differences in glycan expression.
Muhammad Anas Ramzan, Zhedong Yang, Li Cao, Jinyuan Zhang, Fei Wu, Miaomiao Xin, Bo Guo, Lumin Wang, Lingyu Zhao, Yannan Qin, Chengcheng Liu   +10 more
wiley   +1 more source

Combinatorial Fc modifications for complementary antibody functionality. [PDF]

MAbs
Bartsch YC, Webb NE, Burgess E, Kang J, Lauffenburger DA, Julg BD.   +5 more
europepmc   +1 more source

Safety and Efficacy of the First Subcutaneous ICI, Envafolimab, in the Treatment of Advanced Lung Cancer Patients: A Real‐World Study

Thoracic Cancer, Volume 16, Issue 12, June 2025.
This multicenter retrospective study evaluated the efficacy and safety of Envafolimab in advanced lung cancer patients. Envafolimab demonstrates a tolerable safety profile and favorable efficacy. For patients with nonsmall‐cell lung cancer, the analysis identified Eastern Cooperative Oncology Group Performance Status (ECOG PS), tumor stage, and line of
Zixuan Dou, Li Wang, Meng Rui, Yulong Yang, Yunzhi Zhou, JieLi Zhang, Qiuhong Zhao, Mengzhao Wang, Hanping Wang, Xiaotong Zhang, Xiaoxia Cui, Xiaoyan Si, Li Zhang   +12 more
wiley   +1 more source