Results 161 to 170 of about 51,044 (202)

Investigation of the Cooperative Structure of Fc Fragments from Myeloma Immunoglobulin G

Biochemistry, 1998
The cooperative structure of Fc fragments prepared from myeloma human IgG1 was studied using scanning microcalorimetry and fluorescence at pH 4.2-8.0. It was shown that the first to be melted are CH2 domains whose interaction with each other is rather weak, while that with CH3 domains is strong.
V M, Tischenko, V M, Abramov, V P, Zav'yalov   +2 more
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An improved protocol for large scale production of high purity ‘Fc’ fragment of human immunoglobulin G (IgG-Fc)

Journal of Chromatography B, 2020
We describe a simplified approach for purification and characterization of human 'IgG-Fc' fragment used widely as immunochemical tool and for therapeutic purposes. The 'Fc' fragment was purified from human IgG in a 3-stage column chromatography. The purified 'Fc' fragment appeared as a dimer glycoprotein with an apparent molecular mass of 52,981 Dalton
Jatin B, Tandale, Shamkant B, Badgujar, Babasaheb U, Tandale, Unmesh, Angre, Siddharth B, Daftary, Sanjeev, Lala, Vinod P, Gaur   +6 more
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Unsusceptibility of recombinant human Fc fragments of immunoglobulin E to thrombin

Human Antibodies, 1996
Human immunoglobulin E (IgE) contains a potential recognition sequence for thrombin protease cleavage at N-terminal end of Cε3 domain responsible for binding to α chain of high affinity Fc receptor for IgE (FcεRICα, but it remains unknown for the enzyme susceptibility.
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Effective treatment of experimental autoimmune neuritis with Fc fragment of human immunoglobulin

Journal of Neuroimmunology, 2007
IV immunoglobulin (IVIg) and its Fc fragment proved effective in preventing further progression of experimental autoimmune neuritis (EAN) in the rat induced by whole bovine peripheral nerve myelin and shortening disease duration. This effectiveness was associated with significant differences in electrophysiological parameters including less ...
Hsin Hsin, Lin, Min Xia, Wang, Judith M, Spies, John D, Pollard   +3 more
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Expression of Fc Fragment Receptors of Immunoglobulin G (Fc?Rs) in Rat Hepatic Stellate Cells

Digestive Diseases and Sciences, 2005
Hepatic stellate cells (HSCs) are now considered the major cell type in the liver mediating the development of liver fibrosis. Recently it was demonstrated that HSCs express membrane proteins involved in antigen presentation. We further evaluate immunological properties of HSCs by examining the expression and function of the Fc fragment of ...
Hong, Shen, Manna, Zhang, Kelly, Kaita, Gerald Y, Minuk, Julia, Rempel, Yuewen, Gong   +5 more
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ROLE OF Fc FRAGMENTS IN INHIBITION OF XENOGENIC HYPERACUTE REJECTION BY INTRAVENOUS IMMUNOGLOBULIN

Transplantation, 1996
It has been shown that a high dose administration of human intravenous immunoglobulin G (IVIG) prolonged the survival time of xenografted guinea pig heart in the rat. In this study, we compared the effectiveness of intact IVIG (I-IVIG), Fc fragments of IVIG (Fc-IVIG), and F(ab') fragments of IVIG (Fab-IVIG) in preventing xenogenic hyperacute rejection ...
T, Kojima, S, Hayashi, I, Yokoyama, H, Takagi   +3 more
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Preliminary crystallographic study of the Fc fragment of a monoclonal IgG2b murine immunoglobulin

Journal of Molecular Biology, 1983
The Fe fragment of a gamma 2b murine monoclonal anti-p-azophenylarsonate antibody (R19.9, IgG2b, kappa) has been crystallized. The crystals are tetragonal, space group P41 (or P43) with unit cell dimensions: a = b = 134.3 +/- 1.1 A, c = 144.0 +/- 0.7 A.
Comarmond, M, Tougard, P
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Studies on human immunoglobulin G Fc sub-fragments. Structural requirements for biological expression

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1970
Abstract Sub-fragments of the Fc segment of normal human immunoglobulin G have been obtained by papain and pepsin hydrolysis. A comparative study of their physicochemical characteristics and biological activities has been conducted. Except for the Gm “1” allotypic marker, the pepsin sub-fragment, with a molecular weight of half that of Fc, retained ...
D, Frommel, R, Hong
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Genetic (Gm) Antigens associated with Subfragments from the Fc Fragment of Human Immunoglobulin G

Nature, 1969
THE specific (γ) polypeptide chain of immunoglobulin G (IgG, ref. 1) molecules carries several genetic markers (Gm antigens)2,3 which can be detected by serological techniques. Each of the markers is associated with one of three subclasses of γ chain, called γ1, γ2 or γ3 chains4.
M W, Turner, L, Mårtensson, J B, Natvig, H, Bennich   +3 more
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Interference with tolerance induction of primed B cells by the Fc fragment of immunoglobulin

Cellular Immunology, 1984
The capacity to interfere with tolerance induction in primed B cells was examined. Previous work had shown that TNP-specific splenic B cells from mice primed and boosted with TNP-KLH are highly susceptible to in vitro tolerization upon a brief exposure to TNP on a carrier unrelated to KLH.
Walker, S M, Fraker, P J, Weigle, W O
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