Results 171 to 180 of about 51,044 (202)

Aggregated immunoglobulin and Fc fragment of IgG induce IL-6 release from human monocytes

Cellular Immunology, 1990
The Fc fragment of immunoglobulin (Ig) has been shown to play an important role in the regulation of humoral immunity, cellular immunity, lymphocyte and monocyte activation, and immune mediator secretion. We wished to determine if Ig or Fc fragments would induce IL-6 production from monocytes.
Z D, Ling, H J, Ziltener, B T, Webb, D S, Matheson   +3 more
openaire   +2 more sources

Human Immunoglobulin A: Production of an Fc Fragment by an Enteric Microbial Proteolytic Enzyme

The Journal of Immunology, 1973
Summary An Fc fragment has been prepared in good yield by proteolytic cleavage of human secretory and serum myeloma IgA with an enzyme recovered from the human gastrointestinal tract. The naturally occurring enzyme is of microbial origin and its activity is metal dependent.
S K, Mehta, A G, Plaut, N J, Calvanico, T B, Tomasi   +3 more
openaire   +2 more sources

[Isolation of FAB and Fc fragments from murine immunoglobulin G1].

Biulleten' eksperimental'noi biologii i meditsiny, 1979
Two methods of isolating Fab- and Fc-fragments from mouse immunoglobulin G1 are presented. The first method involves fractionation of papain protein hydrolysate on a column with DEAE- (or DE-32)-cellulose adjusted with 0.005 M K-phosphate buffer, pH 8. The Fab-fragment was eluted from the column with the starting buffer.
E L, Beliaeva, B V, Nikonenko, E V, Sidorova   +2 more
openaire   +1 more source

Expression of Fc fragment receptors of immunoglobulin G (Fc gammaRs) in rat hepatic stellate cells.

Digestive diseases and sciences, 2005
Hepatic stellate cells (HSCs) are now considered the major cell type in the liver mediating the development of liver fibrosis. Recently it was demonstrated that HSCs express membrane proteins involved in antigen presentation. We further evaluate immunological properties of HSCs by examining the expression and function of the Fc fragment of ...
Hong, Shen, Manna, Zhang, Kelly, Kaita, Gerald Y, Minuk, Julia, Rempel, Yuewen, Gong   +5 more
openaire   +1 more source

Production of an Fc Fragment from Human Immunoglobulin a by an IgA-Specific Bacterial Protease

1974
Enzymatic proteolysis of human immunoglobulin A yields Fabα fragments but the Fcα is degraded to small peptides. The unavailability of Fcα has hampered to some extent certain studies of IgA, e.g., its primary structure and the attachment site of secretory component and J chain.
A G, Plaut, R J, Genco, T B, Tomasi
openaire   +2 more sources

Bacterial Proteins and Their Proposed Interactions with Fc or Fab Fragments of Immunoglobulins

Biochemistry & Physiology: Open Access, 2014
The reactivity of Immunoglobulin Binding Proteins (IBP) to Fc and/or Fab fragments of immunoglobulins was summarized in this review. Staphylococcal protein A (SpA), Streptococcal protein G and Peptostreptococcal protein L (SpL) were the IBP reported. SpA reacted with IgG from skunk, coyote, raccoon, mule and donkey.
openaire   +1 more source

Isolation of Fab and Fc fragments from mouse immunoglobulin Gl

Bulletin of Experimental Biology and Medicine, 1979
E. L. Belyaeva, B. V. Nikonenko, E. V. Sidorova   +2 more
openaire   +1 more source

Identity of the Fc fragments of pathological and normal human immunoglobulin M

Biochemistry, 1974
G, Florent, D, Lehman, D, Lockhart, F W, Putnam   +3 more
openaire   +2 more sources

Twenty years on: the impact of fragments on drug discovery

Nature Reviews Drug Discovery, 2016
Daniel A Erlanson, Stephen W Fesik, Wolfgang Jahnke   +2 more
exaly  

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

Cell, 2018
Nicola Guzzi, Maciej Ciesla, Phuong Cao Thi Ngoc   +2 more
exaly