Results 161 to 170 of about 415,579 (256)

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Optimization of Sugar-Derivatives Mixtures for Stabilizing Polyclonal Immunoglobulin G in Spray-Dried Inhalable Powders During Processing and Long-Term Storage. [PDF]

Pharmaceutics
Gevenois P, Bui LV, Sebti T, Heyden YV, Amighi K, Wauthoz N.   +5 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Seroprevalence of measles immunoglobulin G antibodies in Bahrain: A cross-sectional study using fever and rash surveillance data (2021-2025). [PDF]

IJID Reg
Alsayyad A, Matar E, Zabar Z, Husain M, Hasan W, Hasan M, Hasan M, Radhi J, Safar BA, Mohamed A.   +9 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

The Immunoglobulin G Glycome: A Modifiable Biomarker and Functional Effector of Aging, Disease, and Mortality

Lauc G, Mijakovac A, Butz E, Vuckovic F, Frkatović-Hodžić A, Kifer D, Deris H, Radovani B, Lukšić F, Cindric A, Gudelj I, Briški NŠ, Josipović G, Yuksel ZS, Ćatić J, Šaler F, Szavits-Nossan J, Hedin C, Šimunović J, Borošak I, Kristic J, Monteiro-Martins S, Pribić T, Hanić M, Pučić-Baković M, Trbojević-Akmačić I, Štambuk T, Štambuk J, Kavur MM, Fančović M, cvetko A, Pezer M, Polašek O, Gornik O, Kiprov D, Verdin E, Younggren B, Newson L, Menni C, Steves C, Spector T, Halfvarsson J, Pochec E, Zabczynska M, Turkalj M, Wilson J, Alarcon-Riquelme M, Aden K, Rosenstiel P, Franke A, Frey N, Schreiber S, Blaak E, Köttgen A, Zoldoš V, Primorac D, Marjanović D, Schultheiss U, Wang W, Rapčan B.   +59 more
europepmc   +1 more source

Blood-Nerve Barrier Breakdown Induced by Immunoglobulin G in Typical and Multifocal Chronic Inflammatory Demyelinating Polyneuropathy and Multifocal Motor Neuropathy. [PDF]

Int J Mol Sci
Shimizu F, Sato R, Mizukami Y, Watanabe K, Maeda T, Kanda T, Matsui N, Misawa S, Izumi Y, Kuwabara S, Nakamori M.   +10 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Inhalative polyclonal immunoglobulin G for the prevention of respiratory infections: A comprehensive <i>in vitro</i> assessment. [PDF]

Int J Pharm X
Rittersberger R, Covini C, Kalgudde S, Kumar P, Voß F, Martin J, Deuter FM, Koslowski G, Dabbars A, Salcher S, Blayac M, Römisch J, Murányi A, Knoch J, Yildirim AÖ, Conlon TM, Schmid O, Hammerschmidt S, Schindowski K.   +18 more
europepmc   +1 more source