Results 201 to 210 of about 442,130 (302)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

The Immunoglobulin G Glycome: A Modifiable Biomarker and Functional Effector of Aging, Disease, and Mortality

Lauc G, Mijakovac A, Butz E, Vuckovic F, Frkatović-Hodžić A, Kifer D, Deris H, Radovani B, Lukšić F, Cindric A, Gudelj I, Briški NŠ, Josipović G, Yuksel ZS, Ćatić J, Šaler F, Szavits-Nossan J, Hedin C, Šimunović J, Borošak I, Kristic J, Monteiro-Martins S, Pribić T, Hanić M, Pučić-Baković M, Trbojević-Akmačić I, Štambuk T, Štambuk J, Kavur MM, Fančović M, cvetko A, Pezer M, Polašek O, Gornik O, Kiprov D, Verdin E, Younggren B, Newson L, Menni C, Steves C, Spector T, Halfvarsson J, Pochec E, Zabczynska M, Turkalj M, Wilson J, Alarcon-Riquelme M, Aden K, Rosenstiel P, Franke A, Frey N, Schreiber S, Blaak E, Köttgen A, Zoldoš V, Primorac D, Marjanović D, Schultheiss U, Wang W, Rapčan B.   +59 more
europepmc   +1 more source

Dynamic monitoring of immunoglobulin G as a prognostic indicator after curative resection in high-risk stage II-III colorectal cancer: a retrospective cohort study. [PDF]

Front Oncol
Sun J, Guo F, Guo Y, Wang N, Feng J.
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Inhalative polyclonal immunoglobulin G for the prevention of respiratory infections: A comprehensive <i>in vitro</i> assessment. [PDF]

Int J Pharm X
Rittersberger R, Covini C, Kalgudde S, Kumar P, Voß F, Martin J, Deuter FM, Koslowski G, Dabbars A, Salcher S, Blayac M, Römisch J, Murányi A, Knoch J, Yildirim AÖ, Conlon TM, Schmid O, Hammerschmidt S, Schindowski K.   +18 more
europepmc   +1 more source

Pholidota‐Inspired Electronic Skin Possessing Terahertz‐Wave Reflection–Absorption–Transmission Switchability

Advanced Science, EarlyView.
The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li, Jiangsong Hou, Yifeng Ruan, Jiang Du, Jun Qiu   +4 more
wiley   +1 more source

Serum <i>Aspergillus</i> Immunoglobulin G as an Independent Biomarker for Extrasinonasal Involvement in Chronic Invasive <i>Aspergillus</i> Rhinosinusitis. [PDF]

Open Forum Infect Dis
Huang JT, Zhou LH, Qiu WJ, Tang H, Zhu RS, Jiang YK, Zhao HZ, Chen ZQ, Zhu LP.   +8 more
europepmc   +1 more source

Disorder‐Induced Extremely Low Thermal Conductivity of Graphite Fluoride

Advanced Science, EarlyView.
This article investigates the effect of fluorination on the thermal conductivity of graphite fluoride, demonstrating the relationship between structural modification and thermal conductivity in an extreme case. The record‐low through‐plane thermal conductivity measured in exfoliated graphite fluoride flakes was found to correlate with the wide ...
Wonsik Lee, Donghoon Moon, Ziyan Qian, Jinwoo Kim, Changheon Kim, Yeojin Lee, Hyobin Yoo, Richard B. Wilson, Qiye Zheng, Gwan‐Hyoung Lee, Hyejin Jang   +10 more
wiley   +1 more source

Polyclonal immunoglobulin G deposits with distinctive appearance in the tubular basement membrane: a report of two cases. [PDF]

BMC Nephrol
Sakamaki Y, Hashiguchi A, Konishi K, Araki T, Tokuyama H.   +4 more
europepmc   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source