Results 231 to 240 of about 442,130 (302)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Immunoglobulin G and C-Reactive Proteins from the Enamel

Indian Journal of Dental Research
S. M. Balaji
doaj   +1 more source

Rapid Glass Wool Enrichment of Glycopeptides for MALDI-MS Analysis of Immunoglobulin G Glycosylation in COVID-19 Samples. [PDF]

J Am Soc Mass Spectrom
Zhou Y, Karlahag F, Weiss SS, Jamshidi S, Tjernberg L, Emmer Å.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease. [PDF]

Front Immunol
Zhao J, Li Y, Ling Y, Wu T, Wu Y, Tan C, Cheng L, Huang D, Liu Y, Zhang Y.   +9 more
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Serum immunoglobulin G glycosylation profiling in breast cancer using a 56-lectin microarray and subtype-specific patterns. [PDF]

Gland Surg
Peng L, Ma M, Zhang Y, Zhang Z, Meng J, Li S, Zhao D, Zhao J, Mao F, Hu C.   +9 more
europepmc   +1 more source

Synergistic Ion Transport and Spatial Confinement in Sb‐Embedded Hollow Carbon Nanofibers for Stable Na Metal Anodes

Advanced Science, EarlyView.
This work presents a 3D Sb‐embedded hollow carbon nanofiber (Sb@HCF) host for ultra‐stable Na metal anodes. Experimental analyses and theoretical simulations clearly uncovers that in situ formed Na‐Sb alloy guides uniform Na deposition and serves as efficient ion transport highways. The Sb@HCF‐based cells achieve exceptional cycling stability in half‐,
Feng Han, Menghuan Yuan, Hui Wang, Baitao Liu, Dezhi Kong, Yongtao Tian, Xinjian Li, Ye Wang, Tingting Xu, Hui Ying Yang   +9 more
wiley   +1 more source

Causal associations of specific immunoglobulin G N-glycosylation subtypes with osteoporosis: A two-sample Mendelian randomization. [PDF]

Jt Dis Relat Surg
Zhao Y, Zhu Y, Zhang W, Wang L, Yan C, Yuan C, Wang L.   +6 more
europepmc   +1 more source