Results 71 to 80 of about 13,142,354 (205)

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Head and neck immunoglobulin G4 related disease: systematic review

, 2018
Immunoglobulin G4 related disease is a recently described systemic syndrome. The head and neck region is the second most common site for presentation after the pancreas.
Del Piero G., Gardenal N., Tirelli G., Quatela E., Gatto A.   +4 more
core   +1 more source

Case report of Mikulicz`s disease: A modern concept of an old entity [PDF]

Vojnosanitetski Pregled, 2016
Introduction. Modern knowlegde defines Mikulicz´s disease as a part of immunoglobulin G4-related disease. The main feature is the presence of lymphoplasmacytic infiltrates, immunoglobulin G4 plasma cells positivity, distinctive storiform ...
Božić Ksenija, Glišić Branislava, Radić-Tasić Olga, Knežević Bojana   +3 more
doaj   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

A case of massive hemoptysis caused by immunoglobulin G4-related respiratory disease in adults: case report and review of literature

Frontiers in Immunology
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated chronic fibro-inflammatory condition, that can involve multiple systems. Immunoglobulin G4-related respiratory disease (IgG4-RRD) is relatively rare, with non-specific clinical symptoms ...
Chun-xia Mei, Guo-long Yue, Xia Feng, Hai-qiao Wu, Jiong Li   +4 more
doaj   +1 more source

Efficacy and Safety of Intralymphatic Immunotherapy With Grass Allergoid and Microcrystalline Tyrosine: A Double‐Blind Randomised Placebo‐Controlled Trial

Allergy, EarlyView.
This is the first randomised placebo‐controlled trial of intralymphatic immunotherapy using a microcrystalline tyrosine‐adjuvanted grass pollen allergoid. Three ultrasound‐guided ILIT injections were well tolerated and reduced combined symptom‐medication scores compared with placebo. The findings support further optimisation and clinical development of
Lara Šošić, Stephan C. Flory, Claudia C. V. Lang, Emma C. Widmer, Alexandra Chabot, Johannes M. Schmid, Tobias Andermatt, David Melillo, Bjarke Hviid‐Vyff, Maibritt Mardahl, Peter Schmid‐Grendelmeier, Thomas M. Kündig, Hans Jürgen Hoffmann, Pål Johansen   +13 more
wiley   +1 more source

Immunoglobulin G4-related sclerosing cholangitis [PDF]

, 2018
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition of which IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation.
Pereira, SP, Webster, G, Goodchild, G
core   +1 more source

Types of Organ Involvement in Patients with Immunoglobulin G4-related Disease

Chinese Medical Journal, 2016
Background: Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic disease that can involve multiple organs and various clinical phenotypes.
Yu Chen, Ji-Zhi Zhao, Rui-E Feng, Ju-Hong Shi, Xue-Mei Li, Yun-Yun Fei, Yang Shi, Wen Zhang, Feng-Chun Zhang   +8 more
doaj   +1 more source

Recent Updates of Immunoglobulin G4-related Pancreatobiliary Disease

The Korean Journal of Gastroenterology, 2020
Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis (IgG4-SC) are the pancreatobiliary manifestations of IgG4-related disease. IgG4-related disease is a newly named fibroinflammatory condition that is characterized by tumefactive ...
Gyu-Chul Lee , Sung-Hoon Moon
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source