Results 51 to 60 of about 17,659 (145)

Think highly of immunoglobulin G4‐related chronic rhinosinusitis as a clinical entity in immunoglobulin G4‐related disease

Eye & ENT Research
IgG4‐related chronic rhinosinusitis (IgG4‐related CRS) is gaining recognition among various specialized physicians. As a systemic disease involving multiple organs, IgG4‐related CRS is still not widely recognized as an independent clinical entity.
Lianqi Wan, Luo Zhang, Yingshi Piao, Yuan Zhang   +3 more
doaj   +1 more source

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, Volume 16, Issue 6, Page 561-571, June 2026.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

Successful treatment of highly advanced immunoglobulin G4-related kidney disease presenting renal mass-like regions with end-stage kidney failure: a case study

BMC Nephrology, 2017
Background Immunoglobulin G4-related kidney disease characterized by immunoglobulin G4-positive plasma cell-rich tubulointerstitial nephritis has distinctive serological and radiological findings.
Hiroyuki Ono, Taichi Murakami, Akira Mima, Eriko Shibata, Masanori Tamaki, Sakiya Yoshimoto, Sayo Ueda, Fumi Kishi, Seiji Kishi, Takashi Kawanaka, Motokazu Matsuura, Kojiro Nagai, Hideharu Abe, Masashi Harada, Toshio Doi   +14 more
doaj   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

Sinonasal immunoglobulin G4-related disease: a case report of an atypical and rare entity

Journal of Medical Case Reports
Background Immunoglobulin G4-related disease is marked by extensive inflammation and fibrosis of an unknown autoimmune component, with an overall incidence ranging from 0.78 to 1.39 per 105 person-years.
Faiq I. Gorial, Nabaa Ihsan Awadh, Shahlaa B. Ali, Sazan Abdulwahab Mirza, Murtadha Hussein Abbas   +4 more
doaj   +1 more source

Immunoglobulin G4-related disease of the ocular adnexa – A case report

Kerala Journal of Ophthalmology
Immunoglobulin G4-related disease of the ocular adnexa is a systemic fibroinflammatory process of unknown etiology characterized by tissue infiltration by Immunoglobulin G4 plasma cells. In this case report, we present a case of Immunoglobulin G4-related
Rahul S. Ranjan, Namrata, Pallavi Prasad, Anil K. Singh   +3 more
doaj   +1 more source

Exosomal Oleic Acid Promotes Lymphangiogenesis and Nodal Metastasis in Cervical Cancer via the AKT/mTOR Pathway

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Cervical cancer exosomes deliver SCD‐dependent oleic acid to LECs, activating AKT/mTOR to drive VEGF‐independent lymphangiogenesis and nodal metastasis, identifying exosomal OA as a therapeutic target. ABSTRACT Cervical cancer (CC) exhibits a pronounced tropism for regional lymphatic dissemination, a process driven by tumor‐associated lymphangiogenesis.
Jinqiu Li, Xiaojing Huang, Guzhalinuer Abulizi, Ayshamgul Hasim   +3 more
wiley   +1 more source

CHD4 Orchestrates Chromatin Remodeling to Activate the c‐Myc Signaling Pathway in Cancer Pathogenesis

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CHD4 plays an essential role as an epigenetic regulator in the pathogenesis of multiple myeloma. The chromatin remodeling protein initially resolves G‐quadruplex (G4) secondary structures within the c‐Myc promoter region, thereby enhancing chromatin accessibility and promoting transcriptional activation.
Pinggang Ding, Yuhao Cao, Zihao Liu, Jingru Xie, Lingling Liu, Shanliang Sun, Xichao Yu, Zhendong Deng, Zhimin Fan, Ye Yang, Chunyan Gu   +10 more
wiley   +1 more source

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Safety and Efficacy of HexaBody‐DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT HexaBody‐DR5/DR5 (GEN1029) is a death receptor 5 (DR5) agonist composed of two humanized immunoglobulin G1 (IgG1) antibodies, Hx‐DR5‐01 and Hx‐DR5‐05, that bind non‐overlapping DR5 epitopes with nanomolar affinity. HexaBody‐DR5/DR5 is designed to activate the TRAIL pathway through DR5 clustering. This phase 1/2a, open‐label, multi‐center study
Marije B. Overdijk, Kristin Strumane, Ruth Plummer, Patricia LoRusso, Jordi Rodon Ahnert, Udai Banerji, Elena Garralda, Emiliano Calvo, Han Si, Naomi Hoevenaars, Jens Thing Mortensen, Sieto Bosgra, Anders Malmberg, Merete Ellekilde‐Pedersen, Teresa Ramirez‐Andersen, Panagiota Diamantopoulou Reiter, Elena Favaro, Ulf Forssmann, Esther C. W. Breij, Maria Jure‐Kunkel   +19 more
wiley   +1 more source