Results 41 to 50 of about 43,330 (313)

The renal and hepatic distribution of Bence Jones proteins depends on glycosylation: a scintigraphic study in rats [PDF]

Brazilian Journal of Medical and Biological Research, 1997
The aim of the present study was to evaluate renal and liver distribution of two monoclonal immunoglobulin light chains. The chains were purified individually from the urine of patients with multiple myeloma and characterized as lambda light chains with ...
M.J.B.A. Prado, A.L. Nicastri, P.L.A. Costa, T. Rockman, I.L.S. Tersariol, H.B. Nader, R.T. Barros, E.B.A. Prado   +7 more
doaj  

Agrin binds to the nerve-muscle basal lamina via laminin [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Altschul, Bowe, Bowe, Bowen, Brancaccio, Brandenberger, Brandenberger, Brubacher, Burden, Burgeson, Campagna, Campanelli, Campbell, Chiu, Cohen, Cohen, Denzer, Denzer, Ferns, Fox, Gautam, Gee, Gesemann, Gesemann, Gluzman, Godfrey, Godfrey, Godfrey, Godfrey, Graham, Hagen, Halfter, Hall, Hunter, Kleinman, Lennon, Lowry, Magill-Solc, Martin, Martin, McMahan, McMahan, Morrissey, Nitkin, Nitkin, Noakes, Ott, Paulsson, Pearson, Perris, Reist, Ries, Ruegg, Ruegg, Ruegg, Rupp, Sanes, Sanes, Sanes, Schuler, Smith, Sugiyama, Timpl, Timpl, Timpl, Tsen, Tsen, Tsim, Wallace, Wallace, Weber, Worton, Yurchenco, Yurchenco   +73 more
core   +3 more sources

Quantifying evolutionary constraints on B cell affinity maturation

, 2014
The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput ...
Bedford, Trevor, Bradley, Philip, Matsen IV, Frederick A., McCoy, Connor O., Minin, Vladimir N., Robins, Harlan   +5 more
core   +2 more sources

The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]

, 2007
Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Cheng Zhu, Periasamy Selvaraj, Timothy P. Tolentino   +2 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. [PDF]

, 1992
Although much has been learned about the molecular basis of immunoglobulin M (IgM) rheumatoid factors (RFs) in healthy individuals and in patients with mixed cryoglobulinemia and rheumatoid arthritis, little is known about the genetic origins of the ...
Carson, DA, Chen, PP, Deftos, M, Huang, DF, Kozin, F, Lu, EW, Olee, T, Soto-Gil, RW   +7 more
core  

Diagnostic and mechanistic implications of serum free light chains, albumin and alpha-fetoprotein in hepatocellular carcinoma [PDF]

, 2014
Background: Mass spectroscopy analysis suggested low serum albumin and high immunoglobulin free light chain (sFLC) levels may have diagnostic value in hepatocellular carcinoma (HCC).
A Leerapun, A Sangiovanni, AA Keshgegian, AM Ward, AR Bradwell, B Terrier, BI Carr, D G Ward, D Schuppan, D Stocken, DG Ward, DG Ward, EE Schwegler, G Torzilli, HW Hann, J Bruix, J Bruix, JA Katzmann, JA Marrero, JE Gottenberg, L Belanger, L K Assi, LK Assi, M Teng, M van der Heijden, MJ Maurer, O Landgren, P J Johnson, PA Bonis, PJ Johnson, PS Kamath, R Aggarwal, R G Hughes, RK Sterling, RN Pugh, S Pirrie, SW Law, TC Poon, VW Wong, Y Nagao   +39 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

An idiotypic cross-reaction between allotype a3 and allotype a negative rabbit antibodies to streptococcal carbohydrates [PDF]

, 1973
Two antibodies to Group C streptococcal carbohydrate isolated from an individual rabbit had similar relative binding affinities for a Group C immuno-adsorbent column.
Kindt, Thomas J., Klapper, David G., Waterfield, Michael D.   +2 more
core   +1 more source