Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Metamorphic proteins (MPs) can fold into two or more distinct spatial structures. Increasing interest in MPs has spurred the search for computational tools to predict proteins fold‐switching potential and model their refolding pathways. Here we address this problem by using the recently reported generative diffusion predictor UFConf, based on ...
Dmitrii A. Luzik, Nikolai R. Skrynnikov
wiley +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Association of Specific Gene Mutations with Immunoglobulin Heavy-Chain Variable Region and Chromosomal Alterations in Chronic Lymphocytic Leukemia Patients in India. [PDF]
Asian Pac J Cancer PrevMani S, Nathany S, Diwan H, Mehta A.
europepmc +1 more source
Polymorphisms in human immunoglobulin heavy chain variable genes and their upstream regions. [PDF]
Nucleic Acids Res, 2020 Mikocziova I +6 more
europepmc +1 more source
Heavy chain-specific suppression of immunoglobulin synthesis and secretion by lymphocytes from patients with selective IgA deficiency. [PDF]
, 1980 Stanley A. Schwartz
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In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini +5 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape. [PDF]
Front ImmunolDeng W +12 more
europepmc +1 more source
Poorly Expressed Alleles of Several Human Immunoglobulin Heavy Chain Variable Genes are Common in the Human Population. [PDF]
Front Immunol, 2020 Ohlin M.
europepmc +1 more source