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Heavy Chains, Heavy Consequences: A Case of Concomitant Heavy Chain Amyloidosis and Heavy Chain Deposition Disease. [PDF]

Kidney Med
Heavy chain (AH) amyloidosis is a rare form of primary systemic amyloidosis that predominantly affects the kidneys and can lead to nephrotic syndrome. It is marked by the deposition of amyloid fibrils derived from immunoglobulin (Ig)-heavy chains.
Amoh BK, Ghanem G, Zuckerman JE, Bruss Z, Chuang K.   +4 more
europepmc   +3 more sources

LICHEN enables light-chain immunoglobulin sequence generation conditioned on the heavy chain and experimental needs [PDF]

Communications Biology
In developing therapeutic antibodies, the heavy chain is often prioritised due to its higher variability and its central role in antigen binding. An appropriate pairing of the light sequence is however important for antibody function.
Henriette L. Capel, Isaac Ellmen, Chris J. Murray, Giulia Mignone, Megan Black, Brendan Clarke, Conor Breen, Sean Tierney, Patrick Dougan, Richard J. Buick, Alexander Greenshields-Watson, Charlotte M. Deane   +11 more
doaj   +2 more sources

Heavy Chain Disease with Cystic Lung Disease Presenting as Recurrent Spontaneous Pneumothorax in a Young Adult [PDF]

Acta Medica Lituanica
Heavy chain diseases (HCDs) are rare B-cell/plasma cell disorders characterized by secretion of truncated immunoglobulin heavy chains without light chains. Pulmonary involvement has been described but is typically limited to interstitial or infiltrative
Konstantinos Dodos, Tsampika Vasileia Kalamara, Vasiliki Epameinondas Georgakopoulou   +2 more
doaj   +2 more sources

Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines

Vaccines, 2022
Leukocyte cell-surface HLA-I molecules, involved in antigen presentation of peptides to CD8+ T-cells, consist of a heavy chain (HC) non-covalently linked to β2-microglobulin (β2m) (Face-1).
Mepur H. Ravindranath, Narendranath M. Ravindranath, Senthamil R. Selvan, Edward J. Filippone, Carly J. Amato-Menker, Fatiha El Hilali   +5 more
doaj   +1 more source

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Antibodies, 2022
Serum anti-HLA-I IgG are present in non-alloimmunized males, cancer patients, and transplant recipients. Anti-HLA-I antibodies are also present in intravenous immunoglobulin (IVIg), prepared from the plasma of thousands of healthy donors.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone   +4 more
doaj   +1 more source

Immune subtraction for improved resolution in serum protein immunofixation electrophoresis and antibody isotype determination in a patient with autoantibody

Practical Laboratory Medicine, 2021
Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah, Nivin Omar, Natasha M. Savage, Roni J. Bollag, Gurmukh Singh   +4 more
doaj   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Dayanithi, G., Ahnert-Hilger, G., Weller, U., Nordmann, J. J., Gratzl, Manfred   +4 more
core   +6 more sources

Flatness of heavy chain systems [PDF]

Proceedings of the 41st IEEE Conference on Decision and Control, 2002., 2001
The paper deals with systems that consist of a fixed length heavy chain suspended from a cart moving along an horizontal line. The whole system is controlled by the motion of the cart. Various types of chains are considered: simple homogeneous chains and variable density chains with or without a weight attached to its free end.
Nicolas Petit, Pierre Rouchon
openaire   +1 more source

Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age

Frontiers in Immunology, 2020
B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied.
Marie Ghraichy, Marie Ghraichy, Jacob D. Galson, Jacob D. Galson, Aleksandr Kovaltsuk, Valentin von Niederhäusern, Valentin von Niederhäusern, Jana Pachlopnik Schmid, Jana Pachlopnik Schmid, Mike Recher, Annaïse J. Jauch, Enkelejda Miho, Enkelejda Miho, Enkelejda Miho, Dominic F. Kelly, Dominic F. Kelly, Charlotte M. Deane, Johannes Trück, Johannes Trück   +18 more
doaj   +1 more source

The validation of artificial anti‐monkeypox antibodies by in silico and experimental approaches

Immunity, Inflammation and Disease, 2023
As a result of smallpox immunization programs that ended more than 40 years ago, a significant portion of the world's population is not immune. Moreover, due to the lack of anti‐monkeypox drugs and vaccines against monkeypox, the spread of this virus may
Sadeq Shabani, Mohsen Rashidi, Shakila Radgoudarzi, Ali Jebali   +3 more
doaj   +1 more source