Gamma heavy chain disease associated with T-cell large granular lymphocyte lymphoproliferative disorder: case report and literature review. [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna +5 more
doaj +2 more sources
Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma [PDF]
Diagnostic Pathology, 2022 Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda +9 more
doaj +2 more sources
Gamma heavy chain disease associated with rheumatoid arthritis: a case report [PDF]
Journal of Medical Case Reports, 2021 Background Gamma heavy chain disease (γ-HCD) is a monoclonal gammopathy defined by an abnormal clonal and isolated production of incomplete heavy chain gamma (γ), unable to bind with light chains kappa or lambda.
Gwenvaël Danic +5 more
doaj +2 more sources
New England Journal of Medicine, 1968 Abstract In a seventh patient with heavy-chain disease the clinical findings were those of a malignant lymphoma without skeletal involvement. The patient's serum and urine contained an M component with electrophoretic, antigenic and ultracentrifugal properties resembling those of the Fc fragment of γG globulin.
L L, Ellman, K J, Bloch
exaly +9 more sources
Heavy Chain Disease with Cystic Lung Disease Presenting as Recurrent Spontaneous Pneumothorax in a Young Adult [PDF]
Acta Medica LituanicaHeavy chain diseases (HCDs) are rare B-cell/plasma cell disorders characterized by secretion of truncated immunoglobulin heavy chains without light chains. Pulmonary involvement has been described but is typically limited to interstitial or infiltrative
Konstantinos Dodos +2 more
doaj +2 more sources
Gamma heavy-chain disease presenting with hypercalcaemia and ascites [PDF]
European Journal of Case Reports in Internal MedicineGamma heavy-chain disease (gHCD) is a rare lymphoproliferative disorder characterised by the production of truncated gamma heavy chains that are not associated with light chains.
Imane El Boutahiri +3 more
doaj +2 more sources
Two Cases of γ-Heavy Chain Disease and a Review of the Literature [PDF]
Case Reports in Hematology, 2018 Gamma heavy chain disease (γ-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, γ-HCD occurs with other lymphoid
I. Ramasamy, Z. Rudzki
doaj +2 more sources
Large-scale paired chain BCR analysis reveals antibody clonal family inference bias and enhances resolution with machine learning. [PDF]
PLoS Computational BiologyA fundamental question in immunology is how the adaptive immune system encodes antigen specificity while maintaining repertoire diversity. B cell receptor (BCR) or antibody clonal families, defined by groups of B cells descending from a common ancestor ...
Hao Wang +8 more
doaj +2 more sources
Gamma heavy chain disease: a retrospective analysis of 6 cases [PDF]
Orphanet Journal of Rare Diseases, 2023 Long Chang, Dao-bin Zhou, Xin-xin Cao
doaj +2 more sources
Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases [PDF]
Haematologica, 2021 Hélène Vergneault +9 more
doaj +2 more sources