Results 11 to 20 of about 1,244,465 (348)

Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma

Diagnostic Pathology, 2022
Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda, Sarah E. Wheeler, David L. Murray, Mindy C. Kohlhagen, Jeffrey A. VosUPMC, Svetlana A. Yatsenko, Mounzer E. Agha, Miroslav Djokic, Steven H. Swerdlow, Nathanael G. Bailey   +9 more
doaj   +1 more source

Clathrin heavy chain is important for viability, oviposition, embryogenesis and, possibly, systemic RNAi response in the predatory mite Metaseiulus occidentalis. [PDF]

PLoS ONE, 2014
Clathrin heavy chain has been shown to be important for viability, embryogenesis, and RNA interference (RNAi) in arthropods such as Drosophila melanogaster.
Ke Wu, Marjorie A Hoy
doaj   +1 more source

The immunoglobulin A isotype of the Arabian camel (Camelus dromedarius) preserves the dualistic structure of unconventional single-domain and canonical heavy chains

Frontiers in Immunology, 2023
IntroductionThe evolution of adaptive immunity in Camelidae resulted in the concurrent expression of classic heterotetrameric and unconventional homodimeric heavy chain-only IgG antibodies.
Walter Conca, Walter Conca, Walter Conca, Soad M. Saleh, Rana Al-Rabiah, Ranjit Singh Parhar, Mahmoud Abd-Elnaeim, Hussein Al-Hindas, Alexander Tinson, Katharina Birgit Kroell, Klaus Roman Liedl, Kate Collison, Uday Kishore, Futwan Al-Mohanna, Futwan Al-Mohanna   +14 more
doaj   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

A simple way to increase recovery of the expressed VH and VL genes in single-sorted human B cells

BioTechniques, 2019
Cloning VH and VL genes from individual antigen-specific B cells is an attractive approach for producing monoclonal antibodies of the desired specificity.
Sergey V Guselnikov, Tatyana N Belovezhets, Sergey V Kulemzin, Andrey A Gorchakov, Alexander V Taranin   +4 more
doaj   +1 more source

A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]

, 2011
The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ, Miss Nicola, Smyllie, Palmer, KJ, Stephens, DJ   +3 more
core   +2 more sources

Novel exons and splice variants in the human antibody heavy chain identified by single cell and single molecule sequencing. [PDF]

PLoS ONE, 2015
Antibody heavy chains contain a variable and a constant region. The constant region of the antibody heavy chain is encoded by multiple groups of exons which define the isotype and therefore many functional characteristics of the antibody.
Christopher Vollmers, Lolita Penland, Jad N Kanbar, Stephen R Quake   +3 more
doaj   +1 more source

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

Gamma heavy chain disease associated with T-cell large granular lymphocyte lymphoproliferative disorder: case report and literature review.

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna, Maria Assunta Limongiello, Stefano Fiori, Maria Stefania De Propris, Irene Della Starza, Stefania Trasarti   +5 more
doaj   +1 more source

γ Heavy chain disease [PDF]

Blood, 2019
![Figure][1] A 78-year-old woman from Sudan with presumed tuberculous lymphadenitis without preexisting autoimmune disease presented with fatigue, persistent fever, hepatosplenomegaly, and generalized lymphadenopathy.
Vidya, Nagrale, Lois, Richard
openaire   +2 more sources