Results 251 to 260 of about 116,527 (269)
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Whale immunoglobulins—II. Heavy chain structure
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1972Abstract 1. 1. Immunoglobulins (7S) were purified from the plasmas of three species of whales, hump-backed, fin-backed and Sei. 2. 2. Heavy polypeptide chains were characterized and compared to human γ chains. 3. 3. Amino acid composition and peptide map comparisons indicated much homology between the whale 7S Ig heavy chain and hyman γ.
Bob G. Sanders, James C. Travis
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Organization of the Human Immunoglobulin Heavy-Chain Locus
1996Immunoglobulin (Ig) heavy-chain (H) genes cluster at three loci in the human genome; the distal region of chromosome 14(1), chromosome 15(2) and chromosome 16(3). Among these only the chromosome 14 locus has been shown to generate a functional Ig gene by recombination of the variable (VH), diversity (D) and joining (JH) segments.
Fumihiko Matsuda, Tasuku Honjo
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Evolution of the Antarctic teleost immunoglobulin heavy chain gene
Molecular Phylogenetics and Evolution, 2010Notothenioid teleosts underwent major modifications of their genome to adapt to the cooling of the Antarctic environment. In order to identify specific features of the Antarctic teleost immunoglobulin, transcripts encoding the constant region of the IgM heavy chain from 13 Antarctic and non-Antarctic notothenioid species were sequenced.
Coscia MR +4 more
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Reassembly of Immunoglobulin M Heavy and Light Chains In Vitro
Scandinavian Journal of Immunology, 1976Reduced and alleviated monoclonal IgM was fractionated into μ and light (L) chains by gel chromatography in 1N acetic acid. Equimolar mixtures of the chains formed a noncovalently bonded structure in 0.01M sodium acetate buffer, pH 4.1, that had the properties of a half subunit.
R. B. Hester, R. E. Schrohenloher
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Primary and secondary variants in immunoglobulin heavy chain production
Nature, 1976WE have isolated numerous variants of a mouse myeloma cell line which synthesised altered heavy immunoglobulin chains and normal light chains after treating the line with the acridine mustard ICR-191 (refs 1–4). The four types of primary variants that we found are shown in Table 1.
Saija Koskimies +2 more
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The role of gene deletion in the immunoglobulin heavy chain switch
Nature, 1980We have examined the arrangement of the genes for the mouse heavy chain subclasses gamma 2b, gamma 2a and gamma 1 by the Southern hybridisation procedure. Evidence has been found for rearrangement involving the gamma 2b and gamma 2a CH genes in the DNA of cells making IgG2b and IgG2a respectively.
Terence H. Rabbitts +3 more
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T-cell idiotypes are linked to immunoglobulin heavy chain genes
Nature, 1976FOUR gene clusters have products that seem to participate in antigen binding on T or B lymphocytes. Three (the genes coding for the heavy and light chains of immunoglobulin molecules) are known to code for structural elements of B-cell receptors for antigen.
Hans Binz, Hans Wigzell, Hervé Bazin
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Translation of human immunoglobulin heavy chain mRNA in vitro
Nature, 1977MOUSE immunoglobulin (Ig) mRNAs have been the subject of intensive study. Purification of Ig light chain mRNAs from myeloma or plasmacytoma cells has been monitored by translation in vitro, and studies have been directed towards sequence determination and gene titration Moreover, partial purification of Ig heavy chain mRNA has also been achieved1–5. No
Frans Cramer +2 more
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Polymorphism of Heavy-Chain Genes in Immunoglobulins of Wild Mice
Science, 1966The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains, 44 of the mice were judged to be heterozygotes of ...
Lieberman, R, Potter, M
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Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus
Current Opinion in Immunology, 2004The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V(H) gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V(H) genes regulates their recombination potential, hence alterations in chromatin are a key factor in allelic exclusion.
Dipanjan Chowdhury, Ranjan Sen
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