Results 121 to 130 of about 35,294 (257)

Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia

, 2009
We analyzed somatic hypermutation (SHM) patterns and secondary rearrangements involving the immunoglobulin (IG) light chain (LC) gene loci in 725 patients with chronic lymphocytic leukemia (CLL).
Stamatopoulos, Kostas, Murray, Fiona,, Chrysoula Belessi, Arvaniti, Eleni, Davi, Frederic, Tanja Smilevska, Anastasia Hadzidimitriou, Eleni Arvaniti, Tresoldi, Cristina, Athanasios Tsaftaris, Hadzidimitriou, Anastasia, Tsaftaris, Athanasios, Nikolaos Laoutaris, Fiona Murray, Achilles Anagnostopoulos, Paolo Ghia, Darzentas, Nikos, Anagnostopoulos, Achilles, Laoutaris, Nikolaos, Richard Rosenquist, Smilevska, Tanja, Nikos Darzentas, Rosenquist, Richard,, Cristina Tresoldi, Kostas Stamatopoulos, Ghia, Paolo, Belessi, Chrysoula, Frederic Davi   +27 more
core   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

PURIFICATION AND PARTIAL CHARACTERIZATION OF SERUM IMMUNOGLOBULIN FROM PERSIAN STURGEON (ACIPENSER PERSICUS)

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2003
In this study, immunoglobulins from serum of Persian sturgeon (Acipenser persicus) were purified and partially characterized. Immunoglobulins were purified from the pooled sera by a combination of salt precipitation, Ion-exchange chromatography and gel ...
M. Kalbasi1; A. Mostafaei2; J. Majidi3
doaj  

Case report: ‘Atypical Richter transformation from CLL-type monoclonal B-cell lymphocytosis into Burkitt lymphoma in a treatment naïve patient’

Frontiers in Oncology
BackgroundRichter transformation refers to the progression of an initially slow-growing small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) into an aggressive lymphoma, typically diffuse large B-cell lymphoma (DLBCL) or Hodgkin lymphoma ...
Annaïse J. Jauch, Ilaria Alborelli, Andreas Reusser, Albert Baschong, Cyrill Rütsche, Olivier Bignucolo, Jakob Passweg, Stefan Dirnhofer, Fatime Krasniqi   +8 more
doaj   +1 more source

Data on the nucleotide composition of the first codons encoding the complementary determining region 3 (CDR3) in immunoglobulin heavy chains. [PDF]

Data Brief, 2018
Thörnqvist L, Ohlin M.
europepmc   +1 more source

The Role of IgM Anti‐acetylated Protein Antibodies and B Cells in the Origin of Antimodified Protein Autoimmunity in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA). In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role ...
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E. M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships. [PDF]

J Immunol, 2019
Zhou JQ, Kleinstein SH.
europepmc   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification

, 2007
Somatic mutations of immunoglobulin genes characterize mature memory B cells, and intraclonal B-cell diversification is typically associated with expansion of B-cell clones with greater affinity for antigen (antigen drive). Evidence for a role of antigen
Bethany E. Beasley, Marc C. Levesque, Barbara K. Goodman, Beasley, Bethany E, Kelsoe, Garnett, Goodman, Barbara K, Volkheimer, Alicia D, John F. Whitesides, J. Brice Weinberg, Alicia D. Volkheimer, Joseph O. Moore, Whitesides, John F, Jon P. Gockerman, Garnett Kelsoe, Moore, Joseph O, Levesque, Marc C, Weinberg, J Brice, Gockerman, Jon P   +17 more
core   +1 more source