Results 251 to 260 of about 1,441,564 (292)
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Rat immunoglobulin E heavy chain locus
Journal of Molecular Biology, 1984A 2100 base-pair long sequence has been established which covers all four constant domains of the rat epsilon-chain. An analysis of messenger RNA from an immunoglobulin E producing rat immunocytoma revealed two separate epsilon-chain mRNA species, 2.3 X 10(3) and 2.8 X 10(3) base-pairs long.
M L, Steen, L, Hellman, U, Pettersson
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Whale immunoglobulins—II. Heavy chain structure
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1972Abstract 1. 1. Immunoglobulins (7S) were purified from the plasmas of three species of whales, hump-backed, fin-backed and Sei. 2. 2. Heavy polypeptide chains were characterized and compared to human γ chains. 3. 3. Amino acid composition and peptide map comparisons indicated much homology between the whale 7S Ig heavy chain and hyman γ.
J C, Travis, B G, Sanders
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J Genes for Heavy Chain Immunoglobulins of Mouse
Science, 1980A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4Aλ phage vector system, was shown to contain the μ heavy chain constant region (C H μ) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of
Newell, N +3 more
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Immunoglobulin heavy-chain constant-region genes
Cell, 1982Antibodies are composed of two identical heavyand light-chain polypeptides. Each heavy and light chain contains an amino-terminal variable (V) region, responsible for antigen recognition, and a carboxy-proximal constant(C) region, which participates in a variety of immunological processes, including effector-cell recognition and complement fixation ...
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Hypervariable Region of Human Immunoglobulin Heavy Chains
Nature New Biology, 1971THE variable regions of human immunoglobulin light chains contain three areas of unusually high variability1–4. Similar hypervariable regions have been postulated for human heavy chains5, 6, but there are no amino-acid sequence data to support this idea.
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Organization of the Human Immunoglobulin Heavy-Chain Locus
1996Immunoglobulin (Ig) heavy-chain (H) genes cluster at three loci in the human genome; the distal region of chromosome 14(1), chromosome 15(2) and chromosome 16(3). Among these only the chromosome 14 locus has been shown to generate a functional Ig gene by recombination of the variable (VH), diversity (D) and joining (JH) segments.
F, Matsuda, T, Honjo
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Addition of glucosamine and mannose to nascent immunoglobulin heavy chains
Biochemistry, 1977We have investigated the process of protein glycosylation in an attempt to answer the question of whether glucosamine and mannose are added to nascent chains prior to chain completion or only to completed chains after release from the ribosome. The MPC 11 mouse plasmacytoma cell line used in these studies synthesizes a glycosylated gamma2b heavy chain ...
L W, Bergman, W M, Kuehl
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Immunoglobulin heavy-chain switching in pre-B leukaemias
Nature, 1983Immunoglobulin gene expression is initiated in pre-B cells by rearrangements of heavy-chain variable genes V, D and J, for transcription together with the constant region gene C mu (refs 1-7). The subsequent joining of light-chain V-J genes in the kappa or lambda families leads to formation of complete IgM molecules, which are then expressed on the ...
H, Kubagawa +3 more
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The role of immunoglobulin heavy chain binding protein in immunoglobulin transport.
Immunology today, 2014More than ten years ago a heavy chain binding protein (BiP) was described which is associated with immunoglobulin heavy chains (HC) within the endoplasmic reticulum (ER) [which is the site of Immunoglobulin (Ig) assembly]. Recently, Linda Hendershot and her collegues suggested that BiP might combine with nascent HC as they enter the ER and hold them ...
L, Hendershot, D, Bole, J F, Kearney
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