Results 271 to 280 of about 62,488 (307)
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Hypervariable Region of Human Immunoglobulin Heavy Chains
Nature New Biology, 1971THE variable regions of human immunoglobulin light chains contain three areas of unusually high variability1–4. Similar hypervariable regions have been postulated for human heavy chains5, 6, but there are no amino-acid sequence data to support this idea.
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Organization of the Human Immunoglobulin Heavy-Chain Locus
1996Immunoglobulin (Ig) heavy-chain (H) genes cluster at three loci in the human genome; the distal region of chromosome 14(1), chromosome 15(2) and chromosome 16(3). Among these only the chromosome 14 locus has been shown to generate a functional Ig gene by recombination of the variable (VH), diversity (D) and joining (JH) segments.
F, Matsuda, T, Honjo
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Addition of glucosamine and mannose to nascent immunoglobulin heavy chains
Biochemistry, 1977We have investigated the process of protein glycosylation in an attempt to answer the question of whether glucosamine and mannose are added to nascent chains prior to chain completion or only to completed chains after release from the ribosome. The MPC 11 mouse plasmacytoma cell line used in these studies synthesizes a glycosylated gamma2b heavy chain ...
L W, Bergman, W M, Kuehl
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Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus
Current Opinion in Immunology, 2004The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V(H) gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V(H) genes regulates their recombination potential, hence alterations in chromatin are a key factor in allelic exclusion.
Dipanjan, Chowdhury, Ranjan, Sen
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Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes
European Journal of Immunology, 1996AbstractSomatic hypermutation of immunoglobulin (Ig) genes plays a critical role in the maturation of the human antibody response. The molecular basis of this important process is, however, unknown. To identify cis‐acting sequences that initiate and target hypermutation, we have made three minitransgenes containing different portions of an Ig heavy ...
J M, Johnston +7 more
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Immunoglobulin heavy-chain switching in pre-B leukaemias
Nature, 1983Immunoglobulin gene expression is initiated in pre-B cells by rearrangements of heavy-chain variable genes V, D and J, for transcription together with the constant region gene C mu (refs 1-7). The subsequent joining of light-chain V-J genes in the kappa or lambda families leads to formation of complete IgM molecules, which are then expressed on the ...
H, Kubagawa +3 more
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Primary and secondary variants in immunoglobulin heavy chain production
Nature, 1976WE have isolated numerous variants of a mouse myeloma cell line which synthesised altered heavy immunoglobulin chains and normal light chains after treating the line with the acridine mustard ICR-191 (refs 1–4). The four types of primary variants that we found are shown in Table 1.
Koskimies, S, Birshtein, B K
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The role of immunoglobulin heavy chain binding protein in immunoglobulin transport.
Immunology today, 2014More than ten years ago a heavy chain binding protein (BiP) was described which is associated with immunoglobulin heavy chains (HC) within the endoplasmic reticulum (ER) [which is the site of Immunoglobulin (Ig) assembly]. Recently, Linda Hendershot and her collegues suggested that BiP might combine with nascent HC as they enter the ER and hold them ...
L, Hendershot, D, Bole, J F, Kearney
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