Results 301 to 310 of about 136,602 (331)

Organization of the Human Immunoglobulin Heavy-Chain Locus

1996
Immunoglobulin (Ig) heavy-chain (H) genes cluster at three loci in the human genome; the distal region of chromosome 14(1), chromosome 15(2) and chromosome 16(3). Among these only the chromosome 14 locus has been shown to generate a functional Ig gene by recombination of the variable (VH), diversity (D) and joining (JH) segments.
Fumihiko Matsuda, Tasuku Honjo
openaire   +3 more sources

Evolution of the Antarctic teleost immunoglobulin heavy chain gene

Molecular Phylogenetics and Evolution, 2010
Notothenioid teleosts underwent major modifications of their genome to adapt to the cooling of the Antarctic environment. In order to identify specific features of the Antarctic teleost immunoglobulin, transcripts encoding the constant region of the IgM heavy chain from 13 Antarctic and non-Antarctic notothenioid species were sequenced.
Coscia MR, Varriale S, De Santi C, Giacomelli S, Oreste U   +4 more
openaire   +5 more sources

Acquired potential N-glycosylation sites within the tumor-specific immunoglobulin heavy chains of B-cell malignancies.

Haematologica, 2004
BACKGROUND AND OBJECTIVES Among B-cell malignancies, follicular lymphomas (FL) more frequently show acquired, potential N-glycosylation sites (AGS) within tumor-specific immunoglobulin. The aim of this study was to extend this observation and to evaluate
N. Zabalegui, A. L. de Cerio, S. Inogés, M. Rodríguez-Calvillo, J. Pérez-Calvo, Milagros Hernández, J. García-Foncillas, S. Martı́n-Algarra, E. Rocha, M. Bendandi   +9 more
semanticscholar   +1 more source

Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl.

Journal of applied physiology, 2005
A variety of immune parameters are modified during and after a spaceflight. The effects of spaceflights on cellular immunity are well documented; however, little is known about the effects of these flights on humoral immunity.
R. Boxio, C. Dournon, J. Frippiat
semanticscholar   +1 more source

Primary and secondary variants in immunoglobulin heavy chain production

Nature, 1976
WE have isolated numerous variants of a mouse myeloma cell line which synthesised altered heavy immunoglobulin chains and normal light chains after treating the line with the acridine mustard ICR-191 (refs 1–4). The four types of primary variants that we found are shown in Table 1.
Saija Koskimies, Saija Koskimies, Barbara K. Birshtein   +2 more
openaire   +3 more sources

Co-translational modification of nascent immunoglobulin heavy and light chains.

Journal of Supramolecular Structure, 1979
We have investigated the in vivo co-translational covalent modification of nascent immunoglobulin heavy and light chains. Nascent polypeptides were separated from completed polypeptides by ion-exchange chromatography of solubilized ribosomes on QAE ...
L. Bergman, W. Kuehl
semanticscholar   +1 more source

Reassembly of Immunoglobulin M Heavy and Light Chains In Vitro

Scandinavian Journal of Immunology, 1976
Reduced and alleviated monoclonal IgM was fractionated into μ and light (L) chains by gel chromatography in 1N acetic acid. Equimolar mixtures of the chains formed a noncovalently bonded structure in 0.01M sodium acetate buffer, pH 4.1, that had the properties of a half subunit.
R. B. Hester, R. E. Schrohenloher
openaire   +3 more sources

Translation of human immunoglobulin heavy chain mRNA in vitro

Nature, 1977
MOUSE immunoglobulin (Ig) mRNAs have been the subject of intensive study. Purification of Ig light chain mRNAs from myeloma or plasmacytoma cells has been monitored by translation in vitro, and studies have been directed towards sequence determination and gene titration Moreover, partial purification of Ig heavy chain mRNA has also been achieved1–5. No
Frans Cramer, Hannah J. Gould, Carol K. Klukas   +2 more
openaire   +3 more sources

Polymorphism of Heavy-Chain Genes in Immunoglobulins of Wild Mice

Science, 1966
The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains, 44 of the mice were judged to be heterozygotes of ...
Lieberman, R, Potter, M
openaire   +3 more sources

The role of gene deletion in the immunoglobulin heavy chain switch

Nature, 1980
We have examined the arrangement of the genes for the mouse heavy chain subclasses gamma 2b, gamma 2a and gamma 1 by the Southern hybridisation procedure. Evidence has been found for rearrangement involving the gamma 2b and gamma 2a CH genes in the DNA of cells making IgG2b and IgG2a respectively.
Terence H. Rabbitts, David Bentley, W. Dunnick, Alan Forster   +3 more
openaire   +2 more sources