Results 371 to 380 of about 280,511 (396)
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Co-translational modification of nascent immunoglobulin heavy and light chains.
Journal of Supramolecular Structure, 1979We have investigated the in vivo co-translational covalent modification of nascent immunoglobulin heavy and light chains. Nascent polypeptides were separated from completed polypeptides by ion-exchange chromatography of solubilized ribosomes on QAE ...
L. Bergman, W. Kuehl
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Translation of human immunoglobulin heavy chain mRNA in vitro
Nature, 1977MOUSE immunoglobulin (Ig) mRNAs have been the subject of intensive study. Purification of Ig light chain mRNAs from myeloma or plasmacytoma cells has been monitored by translation in vitro, and studies have been directed towards sequence determination and gene titration Moreover, partial purification of Ig heavy chain mRNA has also been achieved1–5. No
Frans Cramer +2 more
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Polymorphism of Heavy-Chain Genes in Immunoglobulins of Wild Mice
Science, 1966The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains, 44 of the mice were judged to be heterozygotes of ...
Lieberman, R, Potter, M
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The role of gene deletion in the immunoglobulin heavy chain switch
Nature, 1980We have examined the arrangement of the genes for the mouse heavy chain subclasses gamma 2b, gamma 2a and gamma 1 by the Southern hybridisation procedure. Evidence has been found for rearrangement involving the gamma 2b and gamma 2a CH genes in the DNA of cells making IgG2b and IgG2a respectively.
Terence H. Rabbitts +3 more
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T-cell idiotypes are linked to immunoglobulin heavy chain genes
Nature, 1976FOUR gene clusters have products that seem to participate in antigen binding on T or B lymphocytes. Three (the genes coding for the heavy and light chains of immunoglobulin molecules) are known to code for structural elements of B-cell receptors for antigen.
Hans Binz, Hans Wigzell, Hervé Bazin
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Immunoglobulin heavy-chain switching in pre-B leukaemias
Nature, 1983Immunoglobulin gene expression is initiated in pre-B cells by rearrangements of heavy-chain variable genes V, D and J, for transcription together with the constant region gene C mu (refs 1-7). The subsequent joining of light-chain V-J genes in the kappa or lambda families leads to formation of complete IgM molecules, which are then expressed on the ...
Max D. Cooper +3 more
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Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus
Current Opinion in Immunology, 2004The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V(H) gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V(H) genes regulates their recombination potential, hence alterations in chromatin are a key factor in allelic exclusion.
Dipanjan Chowdhury, Ranjan Sen
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Balanced Synthesis of Light and Heavy Chains of Immunoglobulin G
Nature, 1967WE have already investigated the production of immunoglobulin G (IgG) by mouse plasma cell tumour 5563 and have shown that light chains are released autonomously from polyribosomes into a pool of free light chains. The time course of incorporation of radioactive amino-acids into free light chain and the myeloma protein indicated that the pool of free ...
Brigitte A. Askonas, A. R. Williamson
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Temporal relationship of translation and glycosylation of immunoglobulin heavy and light chains.
, 1978: The initial glycosylation of MPC 11 gamma 2b heavy chains occurs quantitatively in vivo when the nascent heavy chains reach a size of approximately 38 000 daltons.
Bergman Lw, Kuehl Wm
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The Transcription Factor, Bright, and Immunoglobulin Heavy Chain Expression
Immunologic Research, 2001Bright, or B cell regulator of immunoglobulin heavy chain transcription, is a B lymphocyte-specific protein first discovered for its ability to increase immunoglobulin transcription three- to sevenfold in antigen-activated B cells. It interacts with DNA through an ARID, or A/T-rich interaction domain, and is the only member of a previously undescribed ...
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