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Purifying and Measuring Immunoglobulin E (IgE) and Anti-IgE
2013Immunoglobulins (Igs) are a critical component of the adaptive immune system of both man and mouse. The ability to detect and characterize Igs is an invaluable technique for immunology in either a research or a clinical setting. The advent of enzyme-linked immunosorbent assays (ELISAs) and monoclonal antibody technology has proven instrumental for ...
Jamie L, Sturgill, Daniel H, Conrad
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Nasal Polyps and Immunoglobulin E (IgE)
Allergy and Asthma Proceedings, 1996Nasal polyps are usually found in nonallergic individuals. However, when nasal polyps and atopy occur together, a special interaction exists. Total and specific immunoglobulin E (IgE) are found in significantly greater concentration in nasal polyp tissue than in serum and tonsil tissue.
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Immunoglobulin E (IgE) in Middle Ear Effusions
Annals of Otology, Rhinology & Laryngology, 1974This study was undertaken to further clarify the relation of atopic allergy to otitis media with effusion. Ninety-six specimens of middle ear effusions and corresponding sera were collected from 92 patients, and each sample was quantitatively measured by a radioactive single radial diffusion (RSRD) technique for immunoglobulin E (IgE) concentration ...
G, Mogi +4 more
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A new immunoglobulin in allergic rhinitis — (IgE)
The Laryngoscope, 1972AbstractAllergic rhinitis is among the atopic allergic diseases. Sera from patients with atopic disease possess reaginic antibodies that are positive Prausnitz‐Kiistner reaction substances. Recently, a new immunoglobulin class — IgE — was discovered, in which the reaginic antibodies are present in high concentration. The chemical structure and biologic
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Immunoglobulin E (IgE) in patients with severe burns
Burns, 1987The concentrations of immunoglobulin E (IgE) were measured serially in 30 patients with severe burn injury. A characteristic finding was a rapid and dramatic increase of IgE in the serum of all patients, some of whom showed up to 20-fold increases. IgE was also found in considerable amounts in blister fluid and pleural effusions.
V, Polacek +4 more
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A Study of IgE in Immunoglobulin Preparations for Intravenous Administration
Vox Sanguinis, 1986Abstract. We have studied the IgE content of different lots of commercial intravenous IgG preparations used in our day hospital as replacement therapy for patients with agammaglobulinemia. Two enzymatic methods were used: Phadezym and FAST. The average amounts of IgE detected in Endobulin and Sandoglobulin lots were very high with respect to serum ...
R, Paganelli +5 more
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IgE: an immunoglobulin specialized in antigen capture?
Immunology Today, 1990IgE bound to the low-affinity receptor for immunoglobulin E (Fc epsilon R) on antigen-presenting cells (APCs) may permit binding of antigens to APCs prior to their processing and presentation. Here, G. C. Mudde and colleagues argue that the unique characteristics of IgE serological responses together with the distribution of Fc epsilon RII (CD23) on ...
G C, Mudde +4 more
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Regulation of immunoglobulin production in hyper-IgE (Job’s) syndrome
Journal of Allergy and Clinical Immunology, 1999The hyper-IgE (HIE), or Job's, syndrome is a rare, complex disorder characterized by high levels of serum IgE in childhood and chronic dermatitis with recurrent, often severe sinopulmonary and skin infections. Although the etiology of HIE syndrome is unknown, there is evidence that patients with HIE have abnormalities in cellular immune responses, as ...
O, Garraud +6 more
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Immunoglobulin E (IgE) Blockers (Anti-IgE Therapy)
Abstract Immunoglobulin E (IgE), composed of two light chains and two identical heavy chains, is a key component of many allergic diseases such as asthma. It is produced via communication between B and T cells after exposure to foreign allergens.Eric Reilly, Larry Manders
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Function and Structure of Immunoglobulin E (IgE)
1976The function of IgE antibody as mediators in allergic reactions of Type I is explained by their ability to interact both with antigen and with receptor molecules on the membrane of blood basophils and tissue mast cells. However, it is not understood how the interaction of an allergen with cell-bound IgE antibody will induce basophil (mast) cells to ...
H. Bennich +3 more
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