Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (Al). [PDF]
PLoS ONE, 2012 Renal involvement is a frequent consequence of plasma cell dyscrasias. The most common entities are light chain amyloidosis, monoclonal immunoglobulin deposition disease and myeloma cast nephropathy.
Marina Ramirez-Alvarado +7 more
doaj +3 more sources
Germline polymorphisms and alternative splicing of human immunoglobulin light chain genes [PDF]
iScience, 2021 Summary: Inference of germline polymorphisms in immunoglobulin genes from B cell receptor repertoires is complicated by somatic hypermutations, sequencing/PCR errors, and by varying length of reference alleles.
Ivana Mikocziova +5 more
doaj +2 more sources
Genetic pathogenesis of immunoglobulin light chain amyloidosis: basic characteristics and clinical applications [PDF]
Experimental Hematology & Oncology, 2021 Immunoglobulin light chain amyloidosis (AL) is an indolent plasma cell disorder characterized by free immunoglobulin light chain (FLC) misfolding and amyloid fibril deposition.
Linchun Xu, Yongzhong Su
doaj +2 more sources
Localized Immunoglobulin Light-Chain Amyloidosis of the Ulnar Nerve [PDF]
Case Reports in Neurology, 2021 Amyloidosis is a disorder caused by extracellular tissue deposition of insoluble fibrils. Amyloidosis can be divided into systemic or localized disease. Primary systemic amyloidosis is a multisystem disease caused by the deposition of amyloid in various ...
Shinsuke Morisaki +5 more
doaj +2 more sources
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021 [PDF]
Blood Cancer Journal, 2021 Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients ...
M. Hasib Sidiqi, Morie A. Gertz
doaj +2 more sources
Restrictive Atrial Dysfunction in Cardiac Amyloidosis: Differences between Immunoglobulin Light Chain and Transthyretin Cardiac Amyloidosis Patients [PDF]
Biomedicines, 2022 Background: In cardiac amyloidosis, the prevalence of thromboembolic events and atrial fibrillation is higher in transthyretin amyloidosis compared to immunoglobulin light chain amyloidosis.
Mathijs O. Versteylen +3 more
doaj +2 more sources
Clinical characteristics and prognosis of immunoglobulin light chain amyloidosis patients [PDF]
Frontiers in MedicineObjectiveTo analyze the prognostic factors associated with overall survival (OS) in patients diagnosed with immunoglobulin light chain (AL) amyloidosis, with the goal of improving risk stratification and patient management.MethodsA retrospective cohort ...
Lijun Song +9 more
doaj +2 more sources
Chinese consensus on the diagnosis and treatment of immunoglobulin light-chain cardiac amyloidosis. [PDF]
Chin Med J (Engl), 2023 Shen K +8 more
europepmc +2 more sources
99mTc-DPD scintigraphy in immunoglobulin light chain (AL) cardiac amyloidosis. [PDF]
Eur Heart J Cardiovasc Imaging, 2021 Quarta CC +15 more
europepmc +3 more sources
The correlation of left atrial dysfunction and amyloid load in patients with immunoglobulin light-chain cardiac amyloidosis: a 3T cardiac magnetic resonance study. [PDF]
Br J Radiol, 2023 Lu J +7 more
europepmc +3 more sources