Results 171 to 180 of about 394,026 (356)
Advanced Science, Volume 12, Issue 15, April 17, 2025.Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu +8 more
wiley +1 more source
Immunoglobulin Light Chain Amyloidosis: Diagnosis and Risk Assessment. [PDF]
J Natl Compr Canc Netw, 2023 Zanwar S, Gertz MA, Muchtar E.
europepmc +1 more source
Advanced Science, Volume 12, Issue 13, April 3, 2025.MutY homolog (MUTYH) protein levels are significantly decreased in the kidneys of acute kidney injury (AKI) patients. The upregulation of the E3 ligase HUWE1 mediates the degradation of MUTYH in renal tubular epithelial cells, exacerbating DNA damage in both the nucleus and mitochondria, thereby promoting AKI. Targeting the HUWE1/MUTYH pathway may be a
Yunwen Yang +10 more
wiley +1 more source
AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes
Frontiers in ImmunologyIntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more ...
Andrew M. Collins +16 more
doaj +1 more source
Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005. [PDF]
Nat Commun, 2023 Pradhan T +5 more
europepmc +1 more source
Bence Jones Proteins and Light Chains of Immunoglobulins [PDF]
, 1971 Carla L. McLaughlin, Alan Solomon
openalex +1 more source
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
An armed anti-immunoglobulin light chain nanobody protects mice against influenza A and B infections. [PDF]
Sci Immunol, 2023 Liu X +3 more
europepmc +1 more source
Binding Studies on Heavy-Light Chain Recombinant Hybrid Immunoglobulins a Derived from Murine Myeloma Anti-Fructofuranans [PDF]
, 1978 Dirk G. Streefkerk +2 more
openalex +1 more source
NF-KB protein purification from bovine spleen: Nucleotide stimulation and binding site specificity [PDF]
, 1988 The activity of the enhancer for the κ immunoglobulin light chain gene critically depends on the presence in the nucleus of the NF-κB protein. We purified NF-κB over 50,000-fold and identified two protein species, 42 and 44 kDa, that could be eluted and ...
Baltimore, David +3 more
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