Background Cytomegalovirus (CMV) is one of the most frequent pathogens for congenital infections. Most cases of congenital CMV infection (cCMV) are asymptomatic at birth, but sensorineural hearing loss (SNHL) or neurodevelopmental delay can appear later ...
Yuka Torii+11 more
doaj +1 more source
Attractors in residual interactions explain the differentially-conserved stability of Immunoglobulins [PDF]
Proteins belonging to immunoglobulin superfamily(IgSF) show remarkably conserved nature both in their folded structure and in their folding process, but they neither originate from very similar sequences nor demonstrate functional conservation. Treating proteins as fractal objects, without studying spatial conservation in positioning of particular ...
arxiv
Slowly Sedimenting Mercaptoethanol-resistant Antinuclear Factors Related Antigenically to M Immunoglobulins (γ1M-Globulin) in Patients with Systemic Lupus Erythematosus * [PDF]
Naomi F. Rothfield+2 more
openalex +1 more source
Enhancement of Immunoglobulin M Production in B Cells by the Extract of Red Bell Pepper
Under immunocompromised conditions such as aging, cancer, diabetes, burns, and sepsis, external agents may be useful for upregulation of the immune system to prevent infection. Dietary products have the advantage of being safe and easy to take.
T. Goto+4 more
semanticscholar +1 more source
Enhanced Immunoglobulin M and Immunoglobulin G Antibody Titers in Mice Fed Selenium
Mice fed diets supplemented with selenium (sodium selenite) immunologically respond to the sheep red blood cell antigen by producing enhanced immunoglobulin M and immunoglobulin G antibody titers.
J. Spallholz+3 more
semanticscholar +1 more source
Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg+7 more
wiley +1 more source
ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher+5 more
wiley +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier+8 more
wiley +1 more source
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi+6 more
wiley +1 more source
Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study
ABSTRACT Objectives Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess the functional integrity of the corticospinal tract by examining motor evoked potentials (MEPs), Expanded Disability Status Scale (EDSS) scores, magnetic resonance imaging (MRI) lesion counts, and ...
Antonia Bralić+13 more
wiley +1 more source