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Primary Selective Deficiency of Immunoglobulin M
Internal Medicine Journal, 1978Summary: Selective deficiency of IgM as a primary disorder is seldom encountered1–3, and the syndrome remains ill‐defined. It is generally accepted that for a diagnosis to be made, the serum IgM level should be consistently below 2 SD of normal, no other immunodeficiencies are present, and it is not secondary to other disease processes. This report of
Y H, Thong, G M, Maxwell
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Immunochemical studies of an immunoglobulin M-immunoglobulin G mixed cryoglobulin
Clinical Immunology and Immunopathology, 1978Abstract A mixed IgG-IgM cryoglobulin was isolated from a patient with arthritis and glomerulonephritis. Electron microscopic examination of both cryoprecipitate and glomerular deposits revealed unusual structures designated as “cylindrical and annular bodies.” The IgM component was monoclonal and had antibody activity against IgG molecules ...
F, Chenais, H H, Fudenberg, A C, Wang
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Serum sickness-like syndrome after immunoglobulin M-enriched polyclonal immunoglobulin
dmdi, 2010Abstract Medication reactions, infectious etiologies, graft vs. host disease, serum sickness, and serum sickness-like reaction are the most common conditions that cause skin fever and rashes in immunosuppressed patients. In addition to this long list of diseases, severity of the primary disease and deterioration in the patient’s health ...
Fatih Mehmet, Azik +2 more
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Adsorptive voltammetric behaviour of immunoglobulin M
Talanta, 1991The adsorptive voltammetric behaviour of immunoglobulin M (IgM) has been investigated at the static mercury drop electrode. The stripping process yields an analytically useful signal and the detection limit is 1.2 x 10(-10)M. The adsorptive voltammetric behaviour of IgM has been compared with that of IgG and streptavidin.
J M, Fernandez Alvarez +2 more
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Process‐Scale Purification of Immunoglobulin M Concentrate
Vox Sanguinis, 1993AbstractAn IgM concentrate was purified from Cohn fraction III. Efficiency of euglobin precipitation was shown to be controlled by pH and ionic strength. Prekallikrein activator activity in the product was insignificant. Overall yield from the octanoic acid supernate and purity of the concentrate were 66 ± 8 (n = 16) and 50 ± 5% (n = 16), respectively.
P K, Ng +4 more
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Fragmentation of Immunoglobulin
AbstractThis unit describes procedures for fragmentation of IgG to the monovalent Fab fragment using papain digestion, and to the bivalent F(ab′)2 fragment by pepsin digestion. Alternative methods of fragmentation to F(ab′)2 include use of papain that is preactivated with cysteine and use of the enzyme ficin.
Sarah M, Andrew, Julie A, Titus
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Immunoglobulin M as a vaccine adjuvant
Medical Hypotheses, 2011Vaccines are effective in preventing disease by stimulating the immune system and sustaining an immune response towards eradication of pathogens and diseased cells. However, designing successful vaccines is not always straightforward. For a vaccine to be successful, antigen-presenting cells (APC) need to be stimulated, primarily by adjuvants, towards a
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Structure of Human Immunoglobulin M
The Journal of Immunology, 1968Summary A 10.6 S fragment with an approximate molecular weight of 320,000, which represented the Fc portion of the human IgM was isolated by digesting the IgM in the absence of cysteine with activated papain. Comparison of antigenic properties, amino acid composition and carbohydrate content of this fragment with those of the Fc fragment
Tadamitsu Kishimoto +2 more
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Neutralization by Immunoglobulin M
1993The pentameric nature of IgM ensures high avidity (about 107-fold greater than Fab) for structures bearing repeated identical antigenic determinants, but in general IgM is of low specificity since its variable region genes are not subject to hypermutation modification that occurs in cells synthesizing IgG or IgA and increases the affinity of these ...
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