Results 111 to 120 of about 36,827 (300)

Secondary hypogammaglobulinemia in Waldmann's disease treated with subcutaneous immunoglobulins [PDF]

, 2016
Primary intestinal lymphangiectasia (PIL) is rare disorder characterized by congenital malformation or obstruction of intestinal lymphatic drainage; it is responsible for protein losing enteropathy leading to lymphopenia, hypoalbuminemia and ...
Micheletti M, Puccetti A, Tinazzi E, Patuzzo G, Lunardi C.   +4 more
core   +1 more source

Toxic epidermal necrolysis in hemodialysis patient

Advanced Biomedical Research, 2015
Toxic epidermal necrolysis (TEN) is a rare and life-threatening allergic drug reaction. We report a 26-year-old young female with end-stage renal disease on maintenance hemodialysis developing TEN while on filgrastim and phenytoin.
Uday Venkat Mateti, Shankar Prasad Nagaraju, Manohar Bairy, Ravindra Prabhu Attur, Anantha Naik Nagappa, Anuradha Calicut Kini Rao   +5 more
doaj   +1 more source

Efficacy of combined intravenous immunoglobulins and steroids in children with primary immune thrombocytopenia and persistent bleeding symptoms.

, 2014
Background. The aim of this study was to investigate the effect of the combined administration of intravenous immunoglobulins and steroids as a second-line therapy in 34 children with primary immune thrombocytopenia and persistent, symptomatic bleeding.
Matarese SM, Rossi F, Russo G, Giordano P2, Rivetti E, Amendola G6, Parodi E, Mondino A, Farruggia P, Rivetti E3, Davitto M3, Ansaldi G3, Amendola G, Giraudo MT4, Matarese SM7, Mondino A3, Ansaldi G, Davitto M, Parodi E1, Ramenghi U., GIORDANO, Paola, ROSSI, Francesca, Ramenghi U3, Giraudo MT, Farruggia P5, Russo G8   +25 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Intravenous IgM-enriched immunoglobulins in critical COVID-19

, 2022
\(\bf Background:\) A profound inflammation-mediated lung injury with long-term acute respiratory distress and high mortality is one of the major complications of critical COVID-19. Immunoglobulin M (IgM)-enriched immunoglobulins seem especially capable
Timmesfeld, Nina (Prof. Dr.), Neb, Holger (Dr.), Weigand, Markus A. (Prof. Dr.), Rahmel, Tim (PD Dr. med.), Magunia, Harry (Dr. med.), Basten, Jale (M. Sc.), Kindgen‑Milles, Detlef (Prof. Dr. med.), Zimmer, Frieda, Brandenburger, Timo (Dr. med.), Koch, Thea (Prof. Dr. med.), Adamzik, Michael (Prof. Dr. med.), Landgraf, Claudia, Ullrich, Roman (Prof. Dr. med.), Meybohm, Patrick (Prof. Dr. med.), Nierhaus, Axel (Dr. med.), Jarczak, Dominik (Dr. med.), Rosenberger, Peter (Prof. Dr. med.), Haberl, Helge, Achtzehn, Ute (Dr. med.), Zacharowski, Kai (Prof. Dr. Dr.), Dietrich, Maximilian (Dr. med.), Kraft, Felix (MD)   +21 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

A pediatric case of multifocal motor neuropathy with the conduction block

Khyber Medical University Journal
Background: Multifocal motor neuropathy with conduction block (MMNCB) is a rare immune-mediated motor neuropathy, predominantly seen in adults, with few pediatric cases reported.
Saba Zaidi, , Mahzareen
doaj   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source