Results 101 to 110 of about 799,681 (300)

Immunohistochemistry of tissue prepared by a molecular-friendly fixation and processing system

, 2005
A recently introduced histologic fixative (Universal Molecular Fixative [UMFIX]) has been shown to preserve macromolecules in tissue at ambient temperature.
Vincek, V, Morales, A R, Kanhoush, R, Nassiri, M, Nadji, M   +4 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Immunohistochemistry and next-generation sequencing for NTRK fusion detection in differentiated thyroid cancer of children, adolescents and young adults

Introduction: Pan-TRK immunohistochemistry staining can assess the protein expression from NTRK gene fusions. A little is known about its utility in differentiated thyroid cancer samples from children, adolescents, and young adults patients.
Rafael Reis Campos da-Matta, Fabio Hecht, Gabriel Jeferson Rodríguez Machado, Bruno da Silva Lisboa, Alexandre Rolim da-Paz, Leonardo Freitas Boaventura Rios, Juliana Lima von-Ammon, Ana Clara Oliveira Tosta Telles, Taíse Lima Cerqueira de-Oliveira, Fabyan Esberard de Lima Beltrão, Guilherme de Castro Lopes, Helton Estrela Ramos   +11 more
core   +1 more source

Quantitative immunohistochemistry of estrogen receptor in breast cancer: "much ado about nothing!"

, 2008
"The value of a clinical test should be assessed in the overall context of disease management." The ultimate goal of an assay for detection of estrogen receptor (ER) content in breast cancer tissue is to identify patients who will or will not benefit ...
Nadji, Mehrdad
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Computer-aided techniques for Chromogenic Immunohistochemistry: Status and Directions [PDF]

, 2012
Ficarra, Elisa, Di Cataldo, Santa, Macii, Enrico   +2 more
core   +1 more source

HER2 Testing in Breast Carcinoma Very Low Concordance Rate Between Reference and Local Laboratories in Brazil

, 2011
Breast cancer accounts for approximately one quarter of all cancers in females. HER2 gene amplification or HER2 protein overexpression, detected in about 20% of breast carcinomas, predicts a more aggressive clinical course and determines eligibility for ...
Sheila Cristina Lordelo Wludarski, CARVALHO, Filomena M., WEISS, Lawrence M., Lawrence M. Weiss, Berto E Silva, Tácio R., BACCHI, Carlos E., LOPES, Lisandro Ferreira, Carlos E. Bacchi, Filomena M. Carvalho, WLUDARSKI, Sheila Cristina Lordelo, Tácio R. Berto e Silva, Lisandro Ferreira Lopes, SILVA, Tacio R. Berto e   +12 more
core   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

E5 immunohistochemistry.

, 2013
The presence of E5 oncoprotein seen by immunohistochemistry in the cells of chorionic epithelium (black arrows). Insert: corresponding negative control section.
Iolanda Esposito (328374), Roberta Lucà (328377), Michele Cermola (328380), Orlando Paciello (296217), Chiara Urraro (328376), Rosarita Tatè (328379), Sante Roperto (328372), Marita Riccardi (328375), Giuseppe Borzacchiello (328373), Annunziata Corteggio (328378), Franco Roperto (328381)   +10 more
core   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source