Results 221 to 230 of about 853,198 (295)

Atypical Nodular Hidradenoma of the Postauricular Region: A Report of a Rare Case With Radiological, Histopathological, and Immunohistochemical Correlation. [PDF]

Cureus
Chaudhary RP, Khilnani AK, Pillai M, Sardhara S, Bharai P.   +4 more
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Case Report: Pancreatic amphicrine-like carcinoma with acinar differentiation harboring a KANK4-RAF1 gene fusion. [PDF]

Pathol Oncol Res
Kammerer S, Bode P, Schreiber H, Ortega Sanchez G.   +3 more
europepmc   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Case Report: The deceptive vein - when benign-appearing laryngeal lesions mask primary laryngeal classic Kaposi sarcoma. [PDF]

Front Oncol
Eleyan F, Abualia N, Shraim R, Shraim M, Karama A, Altell A, Abulihya M.   +6 more
europepmc   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Cutaneous Adnexal Tumours in an Eastern European Cohort: Clinicopathological Spectrum and Rare Malignant Lesions. [PDF]

Cancers (Basel)
Tinca AC, Manole M, Hagău RD, Ioniță AC, Chiorean DM, Popa V, Sabău AH, Muntean S, Cocuz IG, Cotoi OS.   +9 more
europepmc   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Malignant adenomyoepithelioma of the breast with contralateral homologous tumor and ductal carcinoma <i>in situ</i>: two case reports. [PDF]

Int J Surg Case Rep
Mao Y, Xie L, Zou Y, Che H, Lan H.
europepmc   +1 more source

Is immunohistochemistry a miracle tool?

Medisur, 2017
Caridad Socorro Castro, Alfredo Basilio Quiñones Ceballos   +1 more
doaj   +2 more sources