Results 201 to 210 of about 125,515 (325)

Stereoselective Synthesis of Cannabidiol and its Unnatural Enantiomer to Evaluate Anxiolytic‐Like Properties and Memory Interactions

ChemBioChem, EarlyView.
Both (−)‐ and (+)‐cannabidiol (CBD and ent‐CBD, respectively) are synthesized via a highly diastereoselective CSA‐catalyzed Friedel–Crafts reaction. ent‐CBD exhibits anxiolytic‐like effects in aged male mice without impairing long‐term memory formation.
Marcos Accioly Jr, Kawana Rosa, Andressa G. Soliani, Suzete M. Cerutti, Cristiano Raminelli   +4 more
wiley   +1 more source

Isolated Bilateral Cerebellar Dysfunction as the Initial Manifestation of HIV Infection: A Diagnostic Challenge, Case Report, and Literature Review. [PDF]

Cerebellum
Mondal R, Deb S, Sengupta A, Banerjee S, Ray N, Tiwari M, Roy J, Benito-León J.   +7 more
europepmc   +1 more source

Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The patent foramen ovale (PFO), present in 25% of the population, can cause paradoxical embolism and stroke. Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter‐atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy.
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Georgios Tzimas, Ioannis Skalidis, David Meier, Panagiotis Antiochos, Panagiotis Kostakis, Efthymia Pavlou, Francesco Perone, Georgios Tsivgoulis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis   +13 more
wiley   +1 more source

Recurrent Infections in Allergic Pediatric Patients: An Immune System Problem? A Narrative Review. [PDF]

Children (Basel)
Galván C, Durán R, Matos C, Indolfi C, Klain A.   +4 more
europepmc   +1 more source

Tislelizumab: Structural Innovations and Expanding Clinical Horizons in Next‐Generation PD‐1 Immunotherapy

Chronic Diseases and Translational Medicine, EarlyView.
The interaction of tislelizumab with PD‐1/PD‐L1 in the tumor microenvironment. Tislelizumab targets PD‐1 on T cells, blocking its interaction with PD‐L1 on tumor cells. This action is facilitated by a modified F(ab) region that limits Fc‐γ receptor binding, thereby enhancing the antitumor immune response. ABSTRACT Tislelizumab is a next‐generation PD‐1
Thy T. Nguyen, Bohan Zhang, Luke Zhong, Xiuyi Liang, Letao Bo   +4 more
wiley   +1 more source

Molecular and clinical aspects of histone-related disorders. [PDF]

Hum Genomics
Al Ojaimi M, Banimortada BJ, Alragheb A, Hajir RS, Alves C, Walid D, Raza A, El-Hattab AW.   +7 more
europepmc   +1 more source

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Clinical and immunological features of specific antibody deficiency in a pediatric hospital in Colombia [PDF]

Biomedica
Castaño-Jaramillo LM, Munevar A, Marín AC, Villamil M, Restrepo S, Vélez N.   +5 more
europepmc   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Case Report: Hypomorphic Ligase 4 deficiency - a paradigm of immunodysregulation. [PDF]

Front Immunol
Andrade C, Cordeiro AI, Pinto MV, Neves C, Martins C, Villartay JP, Neves JF.   +6 more
europepmc   +1 more source