Results 41 to 50 of about 591,453 (305)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Personalidad y estabilidad psíquica en un grupo de pacientes adultos con inmunodeficiencia celular Personality and psychic stability in a group of adult patients with cellular immunodeficiency

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2000
Se realizó un estudio de 16 pacientes adultos con el diagnóstico de inmunodeficiencia celular (IC), con el objetivo de evaluar sus características de personalidad, perfil psicopatológico y nivel de ansiedad.
Raúl Martínez Triana, María E Alfonso Valdés, Liana M Serra Felipe   +2 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Carnitine Deficiency Syndromes

, 1990
Carnitine deficiency syndromes manifested as metabolic encephalopathy, lipid storage myopathy, or cardiomyopathy are reviewed from the Department of Pediatrics, Park Nicollet Medical Center, Minneapolis ...
J Gordon Millichap
core   +1 more source

Counseling Framework for HIV-Serodiscordant Couples on the Integrated Use of Antiretroviral Therapy and Pre-exposure Prophylaxis for HIV Prevention [PDF]

, 2017
Background: For HIV-serodiscordant couples, integrated delivery of antiretroviral therapy (ART) for HIV-positive partners and time-limited pre-exposure prophylaxis (PrEP) for negative partners virtually eliminates HIV transmission. Standardized messaging,
Njoroge, John, Bulya, Nulu, Heffron, Renee, Morton, Jennifer F., Tindimwebwa, Edna, Odoyo, Josephine, Baeten, Jared M., Celum, Connie, Wakhungu, Imeldah, Haberer, Jessica, Ngure, Kenneth, Nakyanzi, Agnes, Sedah, Eric, Ongachi, Snaidah, Okwero, Emmanuel   +14 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

A Single Center Survey of Patients With Congenital Neutropenia: Report From Northwestern Iran

Acta Medica Iranica, 2018
Neutropenia is characterized by a decrease in circulating neutrophil counts and consequent infections.  The present study was performed so as to describe the clinical and laboratory findings of patients with congenital neutropenia in northwestern Iran ...
Mahnaz Sadeghi-Shabestari, Samaneh Dousti, Azim Rezamand, Sara Harsini, Nima Rezaei   +4 more
doaj  

136 HIV-1 Nef regulates activity of endoplasmic reticulum chaperone calnexin [PDF]

, 2014
HIV-1 Nef promotes viral replication by downmodulating a number of cell surface transmembrane proteins, such as CD4, MHC-I and MHC-II, which are targeted by Nef to various degradation pathways.
Jennelle, Lucas, Hunegnaw, Ruth, Pushkarsky, Tatiana, Sviridov, Dmitri, Bukrinsky*, Michael, Dubrovsky, Larisa, Fitzgerald, Michael   +6 more
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Immunological study in patients with atopic dermatitis and skin infection by Staphylococcus aureus

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Background: atopic dermatitis is a recurrent chronic disease of the skin, characterized by inflammatory lesions in typical locations. Multiple factors are part of its pathogenesis and evolution; some of them are related to the immune system and to ...
Olga Lina Pupo Rodríguez, María Mercedes Bello Rodríguez, Enelis Reyes Reyes   +2 more
doaj