Results 131 to 140 of about 10,572,916 (223)

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

The Association of Gout Flare Resolution With Physical Activity and Sleep: A Prospective Remote‐Monitoring Study

Arthritis Care &Research, EarlyView.
Objective This study aimed to determine whether gout flare resolution is associated with physical activity and sleep. These findings were intended to inform the future development of a definition for flare resolution. Methods Data from 81 participants with gout who experienced at least one flare during a six‐month prospective observational study were ...
Sarah Stewart, Boston Girven, Mia Clarke, Irene Zeng, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, David Rice, Tania Ka'ai, Karl Rudolph, Julie Collis, Nicola Kayes, Nicola Dalbeth   +12 more
wiley   +1 more source

Generative Artificial Intelligence in Clinical Practice: How Should Rheumatologists Evaluate and Monitor Emerging Tools?

Arthritis Care &Research, EarlyView.
Generative artificial intelligence (AI) is increasingly being used in rheumatology practice, to assist with tasks such as documentation, record summarization, and clinical decision support. Rheumatologists need a practical approach to determining what evidence and oversight each application requires.
Koushan Kouranloo, Mrinalini Dey, Jinoos Yazdany   +2 more
wiley   +1 more source

Association between CD4⁺ T cell counts and gut microbiota and serum cytokines levels in HIV-infected immunological non-responders. [PDF]

BMC Infect Dis, 2021
Lu D, Zhang JB, Wang YX, Geng ST, Zhang Z, Xu Y, Li SY, Wang KH, Kuang YQ.   +8 more
europepmc   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Wenshen Jianpi recipe induced immune reconstruction and redistribution of natural killer cell subsets in immunological non-responders of human immunodeficiency virus/acquired immune deficiency syndrome: a randomized controlled trial. [PDF]

J Tradit Chin Med, 2022
Zhuang T, Jian W, Xin C, Yonghong LI, Yuguang Y, Ao Z, Wen Z, Ying L.   +7 more
europepmc   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Clinical and immunological outcomes of SARS-CoV-2-infected vaccine responders, vaccine non-responders, and unvaccinated patients evaluated for neutralizing monoclonal antibody treatment at a single German tertiary care center: a retrospective cohort study with prospective follow-up

PURPOSE: This study assessed the clinical and immunological outcomes of SARS-CoV-2-infected patients with risk factors for severe disease depending on their immunological status.
Berthele, A., Protzer, U., Hoffmann, D., Pernpeintner, V., Wagner, L., Schneider, J., Renders, L., Christa, C., Minic, M., Vogel, E., Erber, J., Spinner, C. D., Strauß, E.-M., Iakoubov, R., Rothe, K., Voit, F., Willmann, A., Triebelhorn, J;Schneider, J;Spinner, C D;Iakoubov, R;Voit, F;Wagner, L;Erber, J;Rothe, K;Berthele, A;Pernpeintner, V;Strauß, E-M;Renders, L;Willmann, A;Minic, M;Vogel, E;Christa, C;Hoffmann, D;Protzer, U;Jeske, S D, Triebelhorn, J., Jeske, S. D.   +19 more
core   +1 more source

Pre-Digested Protein Enteral Nutritional Supplementation Enhances Recovery of CD4⁺ T Cells and Repair of Intestinal Barrier in HIV-Infected Immunological Non-Responders. [PDF]

Front Immunol, 2021
Geng ST, Zhang JB, Wang YX, Xu Y, Lu D, Zhang Z, Gao J, Wang KH, Kuang YQ.   +8 more
europepmc   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source