Results 41 to 50 of about 1,341,021 (296)
Computational strategies for dissecting the high-dimensional complexity
of adaptive immune repertoires
, 2017 The adaptive immune system recognizes antigens via an immense array of
antigen-binding antibodies and T-cell receptors, the immune repertoire. The
interrogation of immune repertoires is of high relevance for understanding the
adaptive immune response in ...Afzal, Ahmed, Albert, Amanna, Andrews, Angermueller, Apeltsin, Arden, Atchley, Avnir, Barabási, Barak, Bashford-Rogers, Bastian, Baum, Becattini, Ben-Hamo, Berger, Betz, Boc, Bolen, Bolkhovskaya, Bolotin, Bouckaert, Boyd, Boyd, Breden, Brown, Burnet, Bürckert, Calis, Castro, Chang, Chao, Chen, Ching, Cobey, Collins, Corcoran, Covacu, Csardi, Cui, Dash, de Bourcy, DeKosky, DeKosky, DeWitt, Dziubianau, Elhanati, Elhanati, Elhanati, Ellebedy, Emerson, Felsenstein, Friedensohn, Gadala-Maria, Galson, Galson, Geering, Georgiou, Ghraichy, Giribet, Giudicelli, Glanville, Glanville, Glanville, Good, Granato, Greiff, Greiff, Greiff, Greiff, Greiff, Grigaityte, Guindon, Gupta, Gupta, Hagberg, Halliley, Hammarlund, Heather, Hershberg, Hochreiter, Hoehn, Hoehn, Hoehn, Horns, Howie, Iversen, Jackson, Janeway, Jiang, Johnston, Jost, Jurtz, Kaplinsky, Kaplinsky, Kendall, Khavrutskii, Kidd, Kidd, Kidera, Kirik, Konishi, Kumar, Landsverk, Larkin, Lavinder, Laydon, Laydon, Lee, Lee, Lewitus, Li, Lindeman, Lindner, Liu, Love, Lozupone, Madi, Madi, Malissen, Mamoshina, Mangul, Manz, Martin, Meng, Miho, Mora, Morisita, Murugan, Nazarov, Nouri, Oakes, Ostmeyer, Paradis, Parameswaran, Parola, Pinheiro, Pollok, Ralph, Ravn, Reddy, Rempala, Rempala, Revell, Rizzetto, Robinson, Ronquist, Roybal, Rubelt, Rubelt, Safonova, Schliep, Schramm, Schwab, Shannon, Sheng, Sheng, Shlemov, Shugay, Shugay, Shugay, Snir, Snir, Stamatakis, Stern, Strauli, Stubbington, Stubbington, Sun, Sun Cinelli, Swofford, Thomas, Tickotsky, Tonegawa, Torkamani, Trepel, VanDuijn, Venturi, Venturi, Vieira, Vita, Wang, Wardemann, Warren, Watson, Watson, Watson, Weinstein, Wine, Wine, Wu, Yaari, Yaari, Yang, Yeap, Yermanos, Yokota, Yu, Zhu +200 morecore +1 more sourceHyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky +11 morewiley +1 more sourceThe PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén +7 morewiley +1 more sourceCyclic AMP pathway activation and extracellular zinc induce rapid intracellular zinc mobilization in Candida albicans [PDF]
, 2018 LK was supported by Innovation Fund Denmark, DK (4019-00019B). Pcovery ApS received funding from Wellcome Trust, Research Councils, UK (100480/Z/12), Novo Seeds, DK and Boehringer Ingelheim Venture Fund, D.Anja T. Fuglsang, Anne-Marie L. Winther, Duncan Wilson, Lasse Kjellerup, Lasse Kjellerup +4 morecore +3 more sourcesInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more sourceThe laboratory mouse and wild immunology [PDF]
, 2015 The laboratory mouse, Mus musculus domesticus, has been the workhorse of the very successful laboratory study of mammalian immunology. These studies--discovering how the mammalian immune system can work--have allowed the development of the field of wild ...Abolins, S, Lazarou, L, Viney, Mcore +2 more sourcesIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceMathematical models for immunology:current state of the art and future research directions [PDF]
, 2016 The advances in genetics and biochemistry that have taken place over the last 10 years led to significant advances in experimental and clinical immunology.A Bauer, A Bellouquid, A Bellouquid, A Carbo, A Chakraborty, A Chakraborty, A Chavali, A Ghaffari, A Hamdache, A Malkin, A Mander, A Moskalensky, A Nag, A Perelson, A Pigozzo, A Prasad, A Smith, A Smith, A Tóth, B Chen, B Cumming, B Goldstein, B Hancioglu, B Kholodenko, B Kidd, B Rivière, B Rouse, B Su, B Thorne, B Zolnik, C Beauchemin, C Bianca, C Bianca, C Bianca, C Bianca, C Davis, C Dool van den, C Gerlach, C Macnamara, C Pommerenke, C Sinclair, D Bandura, D Barua, D Chen, D Choo, D Coombs, D Finlay, D Kirschner, D Laydon, D Liu, D Mallet, D Mathis, D Smith, D Winter, D Wylie, Doreen A. Cantrell, E Ahrens, E Castillo-Montiel, E Hawkins, E Mochan, E Newell, E Numfor, E Pearce, E Pearce, E Rykiel, E Stirk, F Castiglione, F Castiglione, F Crauste, F Fellizi, F Gross, F Pappalardo, F Pappalardo, G An, G Bogle, G Bogle, G Bonizzi, G Huynh, G Lythe, H Caswell, H Knútsdóttir, H Lee, H Miao, H Miao, H Zheng, I Bains, I Baltcheva, I Nahum-Shani, ID Braber, J Beltman, J Currie, J Day, J Dunster, J Faeder, J Flegg, J Flegg, J Gillard, J Heffernan, J Kim, J Köbig, J Linderman, J Mansfield, J Mattes, J Perley, J Reynolds, J Sekar, J Tan, J Wares, Joseph J. Gillard, K Blyuss, K Fujarewicz, K Ganeshan, K García-Martínez, K Janes, K Murphy, K Norris, K Popper, K Saeki, K Smith, K Yoshida, KH Farh, L Balagopalan, L Bayón, L Borghesi, L Canini, L Canini, L DePillis, L Pillis de, L Romani, M Artyomov, M Chaplain, M Fallahi-Sichani, M Figge, M Halling-Brown, M Itik, M Kalos, M Kolev, M Kolev, M Krummel, M Lever, M Mentis, M Nishikori, M Onsum, M Pogson, M Reed, M Sneddon, N Bellomo, N Bellomo, N Burroughs, N Burroughs, N Burroughs, N Cilfone, N Clifone, N Figueroa-Morales, N Kim, N Kronik, N Oreskes, N Strbo, O Dushek, O Serichantalergs, P Ankomah, P Cao, P Francois, P Gannon, P Johnson, P Kim, P Kim, P Kourilsky, P Morel, P Thagard, P Verdijk, Q Yang, R Andersen, R Antia, R Callard, R Callard, R Cheong, R Cheong, R Eftimie, R Eftimie, R Garnier, R Germain, R Germain, R Leander, R Maizels, R Malka, R Medzhitov, R Saenz, R Spreafico, R Stengel, R Williams, R Zinkernagel, Raluca Eftimie, RD Boer, S Adra, S Andrew, S Basak, S Celli, S Dai, S Gadhamsetty, S Gordon, S Henrickson, S Hoops, S Hugues, S Krishna, S Lawley, S Marino, S Marino, S Meraviglia, S Nagaraja, S Otto, S Prokopiou, S Qi, S Tay, S Villar, S Webb, T Lipniacki, T Sun, T Sun, T Tian, TH Lee, U Foryś, U Ledzewicz, U Schnell, V Ganusov, V Kocabas, W Shou, W Singer, Y Chew, Y Kim, Y Kim, Y Louzoun, Y Vodovotz, Y Vodovotz, Y Wang, YF Qi, Z Feng, Z Feng, Z Kabala, Z Shi, Z Yilmaz +240 morecore +3 more sources
