Results 51 to 60 of about 1,346,937 (297)
History of immunology
Cellular Immunology, 1979 Immunity to disease has long been recognized, but only during the late nineteenth century, thanks to Louis Pasteur, Robert Koch, Elie Metchnikoff and Paul Ehrlich, did immunology become a true science able to explain mechanisms and to develop preventive vaccines.openaire +2 more sourcesGenetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova +25 morewiley +1 more sourceInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceThe laboratory mouse and wild immunology [PDF]
, 2015 The laboratory mouse, Mus musculus domesticus, has been the workhorse of the very successful laboratory study of mammalian immunology. These studies--discovering how the mammalian immune system can work--have allowed the development of the field of wild ...Abolins, S, Lazarou, L, Viney, Mcore +2 more sourcesEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceMathematical models for immunology:current state of the art and future research directions [PDF]
, 2016 The advances in genetics and biochemistry that have taken place over the last 10 years led to significant advances in experimental and clinical immunology.A Bauer, A Bellouquid, A Bellouquid, A Carbo, A Chakraborty, A Chakraborty, A Chavali, A Ghaffari, A Hamdache, A Malkin, A Mander, A Moskalensky, A Nag, A Perelson, A Pigozzo, A Prasad, A Smith, A Smith, A Tóth, B Chen, B Cumming, B Goldstein, B Hancioglu, B Kholodenko, B Kidd, B Rivière, B Rouse, B Su, B Thorne, B Zolnik, C Beauchemin, C Bianca, C Bianca, C Bianca, C Bianca, C Davis, C Dool van den, C Gerlach, C Macnamara, C Pommerenke, C Sinclair, D Bandura, D Barua, D Chen, D Choo, D Coombs, D Finlay, D Kirschner, D Laydon, D Liu, D Mallet, D Mathis, D Smith, D Winter, D Wylie, Doreen A. Cantrell, E Ahrens, E Castillo-Montiel, E Hawkins, E Mochan, E Newell, E Numfor, E Pearce, E Pearce, E Rykiel, E Stirk, F Castiglione, F Castiglione, F Crauste, F Fellizi, F Gross, F Pappalardo, F Pappalardo, G An, G Bogle, G Bogle, G Bonizzi, G Huynh, G Lythe, H Caswell, H Knútsdóttir, H Lee, H Miao, H Miao, H Zheng, I Bains, I Baltcheva, I Nahum-Shani, ID Braber, J Beltman, J Currie, J Day, J Dunster, J Faeder, J Flegg, J Flegg, J Gillard, J Heffernan, J Kim, J Köbig, J Linderman, J Mansfield, J Mattes, J Perley, J Reynolds, J Sekar, J Tan, J Wares, Joseph J. Gillard, K Blyuss, K Fujarewicz, K Ganeshan, K García-Martínez, K Janes, K Murphy, K Norris, K Popper, K Saeki, K Smith, K Yoshida, KH Farh, L Balagopalan, L Bayón, L Borghesi, L Canini, L Canini, L DePillis, L Pillis de, L Romani, M Artyomov, M Chaplain, M Fallahi-Sichani, M Figge, M Halling-Brown, M Itik, M Kalos, M Kolev, M Kolev, M Krummel, M Lever, M Mentis, M Nishikori, M Onsum, M Pogson, M Reed, M Sneddon, N Bellomo, N Bellomo, N Burroughs, N Burroughs, N Burroughs, N Cilfone, N Clifone, N Figueroa-Morales, N Kim, N Kronik, N Oreskes, N Strbo, O Dushek, O Serichantalergs, P Ankomah, P Cao, P Francois, P Gannon, P Johnson, P Kim, P Kim, P Kourilsky, P Morel, P Thagard, P Verdijk, Q Yang, R Andersen, R Antia, R Callard, R Callard, R Cheong, R Cheong, R Eftimie, R Eftimie, R Garnier, R Germain, R Germain, R Leander, R Maizels, R Malka, R Medzhitov, R Saenz, R Spreafico, R Stengel, R Williams, R Zinkernagel, Raluca Eftimie, RD Boer, S Adra, S Andrew, S Basak, S Celli, S Dai, S Gadhamsetty, S Gordon, S Henrickson, S Hoops, S Hugues, S Krishna, S Lawley, S Marino, S Marino, S Meraviglia, S Nagaraja, S Otto, S Prokopiou, S Qi, S Tay, S Villar, S Webb, T Lipniacki, T Sun, T Sun, T Tian, TH Lee, U Foryś, U Ledzewicz, U Schnell, V Ganusov, V Kocabas, W Shou, W Singer, Y Chew, Y Kim, Y Kim, Y Louzoun, Y Vodovotz, Y Vodovotz, Y Wang, YF Qi, Z Feng, Z Feng, Z Kabala, Z Shi, Z Yilmaz +240 morecore +3 more sourcesHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more source
