Results 91 to 100 of about 1,214,228 (245)

National Drugs Advisory Board annual report 1975

, 1975
By the end of 1975. the National Drugs Advisory Board had 15 months of experience in the management of mandatory licensing systems for medicinal products and for manufacturers of pharmaceuticals in Ireland. With few exceptions.
National Drugs Advisory Board (NDAB)
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Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

The prognostic and predictive value of IKZF1 and IKZF3 expression in T-cells in patients with multiple myeloma

OncoImmunology, 2018
Purpose: While recent studies described the role of IKZF1/3 proteins in multiple myeloma (MM) cells, few have highlighted the significance of IKZF1/3 expression in T-cells.
Mohamed H. S. Awwad, Katharina Kriegsmann, Julian Plaumann, Michael Benn, Jens Hillengass, Marc S. Raab, Uta Bertsch, Markus Munder, Katja Weisel, Hans Jürgen Salwender, Mathias Hänel, Roland Fenk, Jan Dürig, Carsten Müller-Tidow, Hartmut Goldschmidt, Michael Hundemer   +15 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Reports of side effects associated with the use of drugs 1982 [PDF]

, 1982
The National Drugs Advisory Board received 540 reports during 1982 from which 1051 side-effects were reported. 39% of the reactions received occurred in association with drugs affecting the central nervous system, over half concerned analgesics, 18% of
National Drugs Advisory Board (NDAB)
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Effects of immunomodulatory drugs on galectin-3 [PDF]

, 2004
Galektin-3, lektin koji specifično prepoznaje -galaktozidne strukture, djeluje kao jak proinflamatorni signal koji modulira staničnu proliferaciju i adheziju, kemotaksiju, fagocitozu te sintezu upalnih medijatora.
Dabelić, Sanja
core   +1 more source

Natural killer cells affect the natural course, drug resistance, and prognosis of multiple myeloma

Frontiers in Cell and Developmental Biology
Multiple myeloma (MM), a stage-developed plasma cell malignancy, evolves from monoclonal gammopathy of undetermined significance (MGUS) or smoldering MM (SMM).
Li Zhang, Li Zhang, Xiaohuan Peng, Xiaohuan Peng, Tao Ma, Tao Ma, Tao Ma, Jia Liu, Jia Liu, Zhigang Yi, Zhigang Yi, Jun Bai, Yanhong Li, Lijuan Li, Lijuan Li, Liansheng Zhang, Liansheng Zhang   +16 more
doaj   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Reports of side effects associated with the use of drugs 1986

, 1986
During 1986 the National Drugs Advisory Board received 1,188 reports of adverse reactions from which 2,454 side effects were recorded. These results represent an increase of approximately 20% in reporting.
National Drugs Advisory Board (NDAB)
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Reports of side effects associated with the use of drugs 1985 [PDF]

, 1985
Halothane In the ten year period of 1970 to 1980 the Board received 9 reports of hepatitis (2 fatal) associated with the repeated use of halothane. This mirrors experience in other countries.
National Drugs Advisory Board (NDAB)
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