Results 31 to 40 of about 169,700 (260)

Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt–Jakob Disease

Frontiers in Neurology, 2020
Objectives: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and sporadic Creutzfeldt–Jakob disease (sCJD) share similar clinical features. Here, we present two unusual cases of anti-NMDAR encephalitis who were misdiagnosed as sCJD at first ...
Jiao Liu, Liyan Chen, Jing Yang, Lan Wang, Huifang Shang, Xueping Chen   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Acute annular outer retinopathy (AAOR)—First report from India

Indian Journal of Ophthalmology. Case Reports, 2023
Acute annular outer retinopathy (AAOR) is a very rare variant of white dot syndrome. Ocular imaging helps in distinguishing it from acute zonal occult outer retinopathy.
Gazal Patnaik, Vinata Rajendran, Lucia Sobrin, Jyotirmay Biswas   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Oral cyclophosphamide monotherapy in advanced resistant ocular cicatricial pemphigoid

Taiwan Journal of Ophthalmology
PURPOSE: The purpose of the study was to study the efficacy of oral cyclophosphamide monotherapy in advanced resistant ocular cicatricial pemphigoid (OCP).
Arash Maleki, Allison Richey, Hasan Bashir, Soheila Asgari, Tate Valerio, Yasmin Massoudi, Andrew Dolinko, Peter Y. Chang, C. Stephen Foster, Stephen D. Anesi   +9 more
doaj   +1 more source

The Challenging Management of Cancer: An Immunonephrologist’s Perspective

Kidney & Blood Pressure Research, 2020
Introduction: Onconephrology is an emerging medical subspecialization that focuses on the numberless interrelations between cancer and kidney diseases. Tumor cells evade immune surveillance through activation of immune checkpoint pathways that suppress ...
Roberta Fenoglio, Dario Roccatello, Emanuele De Simone, Giulio Del Vecchio, Michela Ferro, Giacomo Quattrocchio, Antonella Barreca, Savino Sciascia   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Immunomodulatory therapy for melanoma: Ipilimumab and beyond [PDF]

Clinics in Dermatology, 2013
In 2011, the U.S. Food and Drug Administration approved the first new therapy for melanoma in more than a decade, ipilimumab (Yervoy). Ipilimumab is a novel antibody that blocks cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a regulatory molecule expressed on activated T cells.
Margaret K, Callahan, Michael A, Postow, Jedd D, Wolchok   +2 more
openaire   +2 more sources

SARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy

Frontiers in Immunology
IntroductionMultiple myeloma (MM) is an uncontrolled plasma cell proliferation in the bone marrow, leading to immune dysregulation with impaired humoral immune responses. Conversely, cellular-based responses play a vital role in MM patients. However, the
Ioana Martac, Sina A. Beer, Aileen Schenk, Osama Ahmad, Claus-Philipp Maier, Claus-Philipp Maier, Gülay Demirel, Beate Preuß, Reinhild Klein, Anna M. P. Stanger, Britta Besemer, Luca Hensen, Claudia Lengerke   +12 more
doaj   +1 more source